Vanessa Zaiatz-Bittencourt

TL;DR: It is demonstrated that an essential role for Srebp transcription factors in cytokine-induced metabolic reprogramming of NK cells that was independent of their conventional role in the control of lipid synthesis is demonstrated.

TL;DR: The metabolic changes that occur in peripheral blood NK cells in response to cytokine are defined to be more metabolically active than CD56dim cells, which supports their production of large amounts of IFN-γ during an immune response.

TL;DR: The data suggest that pharmacological inhibition of TGF-β could provide a metabolic advantage to NK cells that is likely to result in improved functional responses, and has important implications for NK cell–based cancer immunotherapies.

TL;DR: In this article, a single-cell analysis, metabolic flux and confocal analysis of NK cells from patients with metastatic breast cancer and healthy controls was performed to investigate if cellular metabolism of circulating NK cells is dysregulated in patients with cancer and if so, to gain insights into potential mechanisms underpinning this.

TL;DR: This paper showed that increased flux through glycolysis and oxidative phosphorylation during the initial cytokine activation period is essential for NK cell training, as is the metabolic signaling factor Srebp.