V
Veeramani Murugan
Researcher at Manonmaniam Sundaranar University
Publications - 4
Citations - 31
Veeramani Murugan is an academic researcher from Manonmaniam Sundaranar University. The author has contributed to research in topics: Binding selectivity & Binding site. The author has an hindex of 3, co-authored 4 publications receiving 27 citations.
Papers
More filters
Journal ArticleDOI
Insights into the binding specificity of wild type and mutated wheat germ agglutinin towards Neu5Acα(2-3)Gal: a study by in silico mutations and molecular dynamics simulations.
Ponnusamy Parasuraman,Veeramani Murugan,Jeyasigamani F. A. Selvin,M. Michael Gromiha,Kazuhiko Fukui,Kasinadar Veluraja +5 more
TL;DR: Double point mutated WGA (WGA3) exhibits increased specificity towards sialylgalactose, and thus, it can be effectively used in targeted drug delivery and as biological cell marker in cancer therapeutics.
Journal ArticleDOI
Theoretical investigation on the glycan‐binding specificity of Agrocybe cylindracea galectin using molecular modeling and molecular dynamics simulation studies
Ponnusamy Parasuraman,Veeramani Murugan,Jeyasigamani F. A. Selvin,M. Michael Gromiha,Kazuhiko Fukui,K. Veluraja +5 more
TL;DR: The double point mutant of ACG2 galectin exhibits enhanced affinity towards α(2,3)‐linked sialyllactose, which can be effectively used as a model for biological cell marker in cancer therapeutics.
Journal ArticleDOI
Theoretical investigation on the binding specificity of fluorinated sialyldisaccharides Neu5Acα(2–3)Gal and Neu5Acα(2–6)Gal with influenza hemagglutinin H1 – A Molecular Dynamics Study
Veeramani Murugan,Ponnusamy Parasuraman,Jeyasigamani F. A. Selvin,M. Michael Gromiha,Kazuhiko Fukui,K. Veluraja +5 more
TL;DR: It was concluded that FN26G should be a better binder for hemagglutinin (H1) than FN23G and it might act as an inhibitor for influenza.
Journal ArticleDOI
Geometry Optimization of Carbohydrate Binding Sites of Influenza: A Quantum Mechanical Approach
Veeramani Murugan,Ponnusamy Parasuraman,Jeyasigamani F. A. Selvin,Thanu R. K. Priyadarzini,M. Michael Gromiha,Kazuhiko Fukui,K. Veluraja +6 more
TL;DR: In this paper, an algorithm to generate input files for quantum mechanical (QM) calculations from molecular dynamics trajectories of protein-carbohydrate complex simulations and QM optimization of binding-site residues of influenza hemagglutinin H1 along with its cell surface receptor sialyldisaccharides Neu5Acα(2→3)Gal (N23G) and Neu 5Acα (2→6)Gal(N26G).