Vered Lewy

TL;DR: In obese adolescents with PCOS, glucose intolerance is associated with decreased first phase insulin secretion, decreased glucose disposition index, and 3) increased hepatic glucose production, which are precursors of type 2 diabetes.

TL;DR: Adolescent girls with PCOS have profound metabolic derangements detected early in the course of the syndrome, including approximately 50% reduction in peripheral tissue insulin sensitivity, evidence of hepatic insulin resistance, and (3) compensatory hyperinsulinemia, which may predict an increased risk of type 2 diabetes mellitus in adolescents with PCos.

TL;DR: Metformin treatment of obese adolescents with PCOS and impaired glucose tolerance is beneficial in improving glucose tolerance and insulin sensitivity, in lowering insulinemia, and in reducing elevated androgen levels.

TL;DR: The hyperinsulinemia observed in AA children is due to both lower insulin clearance and higher insulin secretion compared with their white peers, and the quantitative relationship between insulin secretion and sensitivity is upregulated inAA children.

TL;DR: The data suggest that in African-American children, family history of type 2 diabetes is a risk factor for insulin resistance, and it is proposed that this familial tendency, combined with environmental influences, could lead to type 1 diabetes decades later.