Systems, and components thereof, for analyzing samples These systems include apparatus and methods for generating, transmitting, detecting, and/or analyzing light, including without limitation high-throughput optical screening devices for analyzing samples at one or more assay sites These systems also include apparatus and methods for supporting samples for analysis, including without limitation multiwell sample holders such as microplates

Sample analysis systems

Methods and apparatus for detecting polynucleotide hybridization in luminescence-based assays. The methods may include (1) allele-specific hybridization, using luminescence detection, (2) allele-specific oligonucleotide ligation, using dye-labeled oligonucleotide ligation with luminescence resonance energy transfer (FRET) detection, and (3) allele-specific nucleotide incorporation, using primer extension with luminescence polarization (FP) detection. More specifically, the methods may include (1) locating a sample containing a nucleic acid material at an examination site, (2) illuminating the sample, (3) detecting light transmitted from the sample, and (4) determining the presence, absence, and/or identity of a nucleic acid target in the sample using the light transmitted from the sample.

Methods and apparatus for detecting nucleic acid polymorphisms

Apparatus and methods for performing calorimetry. The apparatus include optical devices for detecting thermal processes and multiwell sample plates for supporting samples for use with such optical devices. The methods include measurement strategies and data processing techniques for reducing noise in measurements of thermal processes. The apparatus and methods may be particularly suitable for extracting thermal data from small differential measurements made using an infrared camera and for monitoring chemical and physiological processes.

Apparatus and methods for infrared calorimetric measurements

Sample-holding devices (124) and systems (90) for efficiently utilizing relatively small-volume fluid samples

Sample-holding devices and systems

Reference fiducials for sample holders. The reference fiducials may be configured to provide information that facilitates sample handling and/or analysis. The sample holders may include microplates and biochips.

Verner B. Andersen

Papers

Analysis plate with matching lid for biological purposes