Victor Hugh Perry

TL;DR: Both acute and chronic systemic inflammation, associated with increases in serum tumor necrosis factor α, is associated with an increase in cognitive decline in Alzheimer disease.

TL;DR: The question as to what extent different activation states of microglia exist in the human central nervous system is discussed, which tools can be used to identify them and emerging evidence for such changes in ageing and in Alzheimer's disease is discussed.

TL;DR: From morphologic evidence and comparison of labelling indices at different survival times, it is concluded that resident microglia can synthesise DNA and go on to divide in situ; cells are recruited from the circulating monocyte pool through an intact blood-brain barrier and rapidly differentiate into residentmicroglia.

TL;DR: Capillary and artery basement membranes act as ‘lymphatics of the brain’ for drainage of fluid and solutes; such drainage appears to require continued cardiac output as it ceases following cardiac arrest.

TL;DR: A neuropathological correlate of an early behavioural deficit in prion disease is demonstrated and it is suggested that this should allow insights into the first steps of the neuropathogenesis of prion diseases.