V
Victor J. Ferrans
Researcher at National Institutes of Health
Publications - 289
Citations - 26001
Victor J. Ferrans is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Lung & Myocyte. The author has an hindex of 86, co-authored 289 publications receiving 25353 citations. Previous affiliations of Victor J. Ferrans include Center for Devices and Radiological Health & Academia Nacional de Medicina.
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Journal ArticleDOI
Requirement for Generation of H2O2 for Platelet-Derived Growth Factor Signal Transduction
TL;DR: The results suggest that H2O2 may act as a signal-transducing molecule, and they suggest a potential mechanism for the cardioprotective effects of antioxidants.
Journal Article
Inflammatory and immune processes in the human lung in health and disease: evaluation by bronchoalveolar lavage.
TL;DR: From the data already acquired, it is apparent that bronchoalveolar lavage will yield major insights into the pathogenesis, staging, and therapy decisions involved in these disorders.
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Ras Proteins Induce Senescence by Altering the Intracellular Levels of Reactive Oxygen Species
Andrew C. Lee,Brett E. Fenster,Hideki Ito,Kazuyo Takeda,Nancy S. Bae,Tazuko H. Hirai,Zu Xi Yu,Victor J. Ferrans,Bruce H. Howard,Toren Finkel +9 more
TL;DR: It is suggested that in normal diploid cells, Ras proteins regulate oxidant production and that a rise in intracellular H2O2 represents a critical signal mediating replicative senescence.
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Reactive oxygen species are downstream mediators of p53-dependent apoptosis
TL;DR: P53 acts to regulate the intracellular redox state and induces apoptosis by a pathway that is dependent on ROS production, and in sensitive cells, both ROS production and apoptosis were inhibited by antioxidant treatment.
Journal ArticleDOI
Regulation of reactive-oxygen-species generation in fibroblasts by Rac1.
Maitrayee Sundaresan,Zu-Xi Yu,Victor J. Ferrans,D J Sulciner,J S Gutkind,Kaikobad Irani,Pascal J. Goldschmidt-Clermont,Toren Finkel +7 more
TL;DR: These results provide the first demonstration of the pathway by which ligand stimulation of ROS occurs in non-phagocytic cells and suggest that the family of Ras-related small GTP-binding proteins may function as regulators of the intracellular redox state.