V
Vidita A. Vaidya
Researcher at Tata Institute of Fundamental Research
Publications - 106
Citations - 5420
Vidita A. Vaidya is an academic researcher from Tata Institute of Fundamental Research. The author has contributed to research in topics: Hippocampal formation & Neurogenesis. The author has an hindex of 37, co-authored 98 publications receiving 4830 citations. Previous affiliations of Vidita A. Vaidya include Yale University & University of Oxford.
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5-HT2A receptor-mediated regulation of brain-derived neurotrophic factor mRNA in the hippocampus and the neocortex.
TL;DR: The results of this study raise the possibility that regulation of BDNF expression by hallucinogenic 5-HT2Areceptor agonists leads to adaptations of synaptic strength in the hippocampus and the neocortex that may mediate some of the acute and long-term behavioral effects of these agents.
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Differential regulation of brain derived neurotrophic factor transcripts by antidepressant treatments in the adult rat brain.
TL;DR: The results indicate that distinct antidepressants differentially regulateBDNF mRNAs through a region-specific recruitment of the four BDNF promoters and suggest that diverse signaling mechanisms may be recruited to regulate BDNF transcripts.
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Hippocampal mossy fiber sprouting induced by chronic electroconvulsive seizures.
TL;DR: It is suggested that increased expression of brain-derived neurotrophic factor is necessary, but not sufficient for the induction of this sprouting, and sprouting of the mossy fiber pathway would appear to oppose the actions of stress and could thereby contribute to the therapeutic actions of electroconvulsive seizure therapy.
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Thyroid hormone regulates hippocampal neurogenesis in the adult rat brain
Lynette A. Desouza,Uma Ladiwala,Sarah M. Daniel,Shubhada Agashe,Rama Vaidya,Vidita A. Vaidya +5 more
TL;DR: In vivo and in vitro results support a role for thyroid hormone in the regulation of adult hippocampal neurogenesis and raise the possibility that altered Neurogenesis may contribute to the cognitive and behavioral deficits associated with adult-onset hypothyroidism.
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Depression – emerging insights from neurobiology
Vidita A. Vaidya,Ronald S. Duman +1 more
TL;DR: The molecular mechanisms underlying the effects of antidepressant treatments including adaptations in the cAMP transduction cascade, CREB and BDNF gene expression, and structural neuronal plasticity are discussed.