Showing papers by "Vincent Cottin published in 2003"
TL;DR: This study shows the clinician should remain alert to potential muscular or cutaneous manifestations whenever a pathological diagnosis of nonspecific interstitial pneumonia is made.
Abstract: This study investigated interstitial pneumonia associated with amyopathic dermatomyositis, dermatomyositis and polymyositis, paying particular attention to muscular and/or cutaneous manifestations and their chronology relative to lung involvement. Patients included four males and 13 females, aged 51.7+/-10.8 yrs, who had surgical lung biopsy. Diagnoses included dermatomyositis (10 patients), polymyositis (four patients) and amyopathic dermatomyositis (three patients). Solitary respiratory manifestations preceded the onset of any skin or muscle disease in four cases (24%). Reticular and ground glass opacities were the most frequent computed tomography (CT) findings. Pathological review showed nonspecific interstitial pneumonia (eleven, 65%; cellular, two; cellular and fibrotic, five; fibrotic, four), usual interstitial pneumonia (two), organising pneumonia (two), lymphocytic interstitial pneumonia (one), and unclassifiable interstitial pneumonia (one). Nonspecific interstitial pneumonia was the most common histological pattern of interstitial pneumonia in patients with amyopathic dermatomyositis (three of three) and in patients with respiratory symptoms as the initial clinical manifestation of the connective tissue disease (three of four). Survival at 5 yrs was 50%. This study shows the clinician should remain alert to potential muscular or cutaneous manifestations whenever a pathological diagnosis of nonspecific interstitial pneumonia is made.
232 citations
TL;DR: The present observation suggests that Cowden’s disease may include mesenchymal cystic hamartoma of the lung, a rare clinicopathological entity characterized by a cystic pulmonary lesion with typical pathological features.
14 citations
Journal Article•
TL;DR: Churg-Strauss syndrome is a vasculitis associated with asthma and eosinophilia with generally severe and often steroid-dependent late-onset asthma associated with allergic rhinitis and sometimes nasal polyposis and recurrent sinusitis.
Abstract: Churg-Strauss syndrome is a vasculitis associated with asthma and eosinophilia Respiratory involvement is marked by generally severe and often steroid-dependent late-onset asthma associated with allergic rhinitis and sometimes nasal polyposis and recurrent sinusitis Asthma generally precedes the systemic vasculitis by a few years General signs, eosinophilic gastroenteritis, peripheral multiplex neuropathy, cutaneous vasculitis, nephropathy, or arthromyalgia, predominate Cardiac involvement is often silent but of severe prognosis The chest X-ray usually shows irregularly delimited and sometimes labile infiltrates Perinuclear antineutrophil cytoplasmic autoantibodies (ANCA) are found in two-thirds of the patients and strongly suggest the diagnosis Clinically, the diagnosis is established by the presence of asthma, peripheral eosinophilia > 15 G/L, and systemic vasculitis involving at least two extra-pulmonary organs Histological confirmation is usually necessary (nerve and muscle biopsy), showing small-vessel eosinophilic vasculitis, tissue infiltration with eosinophils, and eosinophilic granulomas Treatment includes corticosteroids, which should be associated with immunosuppressive agents (cyclophosphamide) in severe cases
13 citations