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Showing papers by "Vittorio Romano published in 1983"

Journal Article•DOI•
Cloning and sequencing of a full length cDNA coding for human retinol-binding protein

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Vittorio Colantuoni1, Vittorio Romano, G. Bensi, Claudio Santoro2, Francesco Costanzo1, G. Raugei, Riccardo Cortese •
University of Naples Federico II1, University of Turin2
25 Nov 1983-Nucleic Acids Research
TL;DR: The sequence indicates that Retinol Binding Protein is synthesized as a single polypeptide chain precursor which is then matured to the secreted protein by removal of a leader peptide.
Abstract: We have isolated and sequenced a cDNA clone coding for human Retinol Binding Protein. The sequence indicates that Retinol Binding Protein is synthesized as a single polypeptide chain precursor which is then matured to the secreted protein by removal of a leader peptide. Southern and Northern blot analysis suggest that the gene is present in one or few copies per haploid genome and is transcribed in a single mRNA species.

92 citations

Journal Article•DOI•
Sequence of human haptoglobin cDNA: evidence that the alpha and beta subunits are coded by the same mRNA.

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G. Raugei, G. Bensi, Vittorio Colantuoni1, Vittorio Romano, Claudio Santoro2, Francesco Costanzo1, Riccardo Cortese •
University of Naples Federico II1, University of Turin2
10 Sep 1983-Nucleic Acids Research
TL;DR: The sequence shows that haptoglobin is very likely synthesized as a single polypeptide chain which is then cleaved at an Arg residue to generate its two characteristic alpha and beta subunit.
Abstract: We have isolated and sequenced a cDNA clone coding for human haptoglobin. Our sequence shows that haptoglobin is very likely synthesized as a single polypeptide chain which is then cleaved at an Arg residue to generate its two characteristic alpha and beta subunit. Southern blot analysis suggests that there are at least two copies of the haptoglobin gene per haploid genome.

57 citations