W
W G Humphreys
Researcher at Vanderbilt University
Publications - 2
Citations - 149
W G Humphreys is an academic researcher from Vanderbilt University. The author has contributed to research in topics: Adduct & Peroxidase. The author has an hindex of 2, co-authored 2 publications receiving 147 citations.
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Mechanism of C8 alkylation of guanine residues by activated arylamines: evidence for initial adduct formation at the N7 position
TL;DR: These products are uniquely consistent with a scheme in which C8-adduct formation is preceded by an initial electrophilic substitution on the N7 atom, which is postulated to be a general reaction for activated arylamines and heterocyclic amines.
Journal Article
Mechanisms of cytochrome P450 1A2-mediated formation of N-hydroxy arylamines and heterocyclic amines and their reaction with guanyl residues.
F. P. Guengerich,W G Humphreys,Chul-Ho Yun,George Hammons,Fred F. Kadlubar,Yasuo Seto,O. Okazaki,Martha V. Martin +7 more
TL;DR: Evidence is presented that the major C8-guanyl DNA adducts resulting from these arylamines and heterocyclic amines in DNA may be formed via rearrangement of an initial N7-guanosinyl-2-arylamine adduct.