Cellulose biosynthesis and function in bacteria.

Chemistry and metabolism of lipids in the vertebrate retina

(First of Two Parts) COLLAGEN is the major macromolecule of most connective tissues, and it is widely believed that many human diseases, particularly chronic diseases, will be found to involve this protein either directly or indirectly. Since collagen biosynthesis was last reviewed in the Journal in 1972,1 much new information has been gained about the relatively complex pathway by which it is synthesized. We should like to consider this new information and some of its consequences in terms of the following questions: What is the structural information in the collagen molecule, and how does it determine the structure of the . . .

Biosynthesis of collagen and its disorders

Glucose reacts nonenzymatically with the NH2-terminal amino acid of the beta chain of human hemoglobin by way of a ketoamine linkage, resulting in the formation of hemoglobin AIc. Other minor components appear to be adducts of glucose 6-phosphate and fructose 1,6-diphosphate. These hemoglobins are formed slowly and continuously throughout the 120-day life-span of the red cell. There is a two- to threefold increase in hemoglobin AIc in the red cells of patients with diabetes mellitus. By providing an integrated measurement of blood glucose, hemoglobin AIc is useful in assessing the degree of diabetic control. Furthermore, this hemoglobin is a useful model of nonenzymatic glycosylation of other proteins that may be involved in the long-term complications of the disease.

https://science.sciencemag.org/content/sci/200/4337/21.full.pdf

The glycosylation of hemoglobin: relevance to diabetes mellitus

A new dominant hybrid selective marker for higher eukaryotic cells.

PERSPECTIVES AND SUMMARY .... 95 MONOSACCHARIDE DERIVATIVES OF DOLICHOL .... ........ ..... ..... ......... 97 Biosynthesis and Structure 97 Other Lipid-Linked Monosaccharides 102 OLIGOSACCHARIDE-LIPIDS 103 Glucose-Containing Oligosaccharide-Lipids 103 Mannose-Containing Oligosaccharide-Lipids "'''''''''''''''''''''''''''''''''''''''''''''''''''''''''' 104

W J Lennarz

Papers

The role of polyprenol-linked sugars in glycoprotein synthesis.