Showing papers by "Wadih Arap published in 2011"
Patent•
08 Feb 2011TL;DR: In this article, retro-inverted peptides are used as soluble decoys for TGF-α and/or EGF, and anti-cancer properties of these decoys are demonstrated both in vitro and in vivo.
Abstract: Provided are peptides which can mimic the epidermal growth factor receptor (EGFR), e.g. , by selectively binding TGF-α and/or EGF. In certain embodiments, the peptides are retro-inverted peptides. The peptides may be used as soluble decoys for TGF-α and/or EGF, and anti-cancer properties of peptides are demonstrated both in vitro and in vivo . The peptides may be administered alone or comprised in a fusion construct, imaging construct, and/or a therapeutic construct, e.g. , for the treatment of a cancer.
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