Identification of a druggable protein-protein interaction site between mutant p53 and its stabilizing chaperone DNAJA1.

An intelligent prediction system has been developed to discriminate drug-like and non drug-like molecules pattern. The system is constructed by using the application of advanced version of standard multilayer perceptron (MLP) neural network called Hybrid Multilayer Perceptron (HMLP) neural network and trained using Modified Recursive Prediction Error (MRPE) training algorithm. In this work, a well understood and easy excess Rule of Five + Veber filter properties are selected as the topological descriptor. The main idea behind the selection of this simple descriptor is to assure that the system could be used widely, beneficial and more advantageous regardless at all user level within a drug discovery organization.

Wan Mohd Fairuz Wan-Mamat

Papers

Drug-like and non drug-like pattern classification based on simple topology descriptor using hybrid neural network.