Showing papers by "Wannian Zhang published in 2001"
Journal Article•
TL;DR: Results show that zinc chlorin e4(1) has significant protective effect against indomethacin-induced gastric lesion in rats and TAA or CCl4 induced acute liver injuries in mice, and it is suggested that 1 may be a promising new drug candidate for antigastrelcosis and liver injury protection.
Abstract: AIM To study the synthesis of zinc chlorin e 4 (1), its experimental antigastrelcosis activity as well as the protection against acute liver injuries. METHODS Chlorin e 6 (3) was prepared through acidic and alkaline oxidative degradation using silkworm excrement crude chlorophyll extracts as starting material. Compound 1 was synthesized via Zn(OAc) 2 complex action with Chlorin e 4 (2) which was prepared by refluxing 3 in pyridine. Gastric ulcers were induced by abdominal injection of 0 2% indomethacin at 20 mg·kg -1 in rats. The ulcer indexes and ulcer numbers in gastric mucosa were determined. Acute liver injuries were induced by abdominal injection of 0 3% thioacetamide (TAA) or 0 3% CCl 4 at 20 mg·kg -1 in mice, and activities of SGPT in mice were determined. RESULTS Compound 1 is previously unknown. Compared with control group, abdominal administration of 1 at 100 mg·kg -1 reduced significantly the gastric ulcer index ( P 0 001) and the number of ulcer ( P 0 001) induced by indomethacin in rats. Abdominal administration of 1 at 100 mg·kg -1 ×3 exhibited marked inhibitory effects on elevated activities of SGPT induced by TAA ( P 0 02) or CCl 4 ( P 0 01) in mice. CONCLUSION These results show that 1 has significant protective effect against indomethacin induced gastric lesion in rats and TAA or CCl 4 induced acute liver injuries in mice. It is suggested that 1 may be a promising new drug candidate for antigastrelcosis and liver injury protection.
4 citations
Patent•
25 Apr 2001
TL;DR: A triazole alcohol type antifungal compound and its preparation method is described in this paper. But this compound is not suitable for use in medical applications, as it is high in activity and low in toxicity.
Abstract: The present invention provides a triazoazole alcohol type antifungal compound and its preparation method, i.e, 1-(1H-1,2,4-triazole-1-radical)-2-(2,4-difluorophenyl)-3-(N-methyl-N-substituted benzylamino)-2-propanol compound. Its synthesis process includes the following steps: making m-difluorobenzene undergo the process of chloracetyl chloride acylation, connecting triazoazole, and epoxidizing to produce 1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4 triazole methylsulfonate, substituting toluene and brominating, and reacting with methylamine to obtain the substituent-N-methyl-benzylamine, and making substituent-N-methyl-benzylamine and 1-[2-(2,4-difluorophyenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole methylsulfonate produce reaction to obtain the invented object compound. Said compoundis high in activity, low in toxicity, broad in antifungal spectrum, can be used for preparing antifungal medicine.
3 citations