Weiming Yan

TL;DR: This review summarizes current concepts of immune‐mediated liver injury from both clinical studies and animal models and highlights immune responses of ALF from the liver injury perspective, which combines a variety of molecular and cellular mechanisms, particularly, the contribution of cytokines and the innate immune system.

TL;DR: NK cells play a pivotal role in the pathogenesis of FHF and HBV-ACLF, in which process Fas/FasL and NKG2D/NKG 2D ligand pathway contribute to the liver NK cell-mediated hepatocyte injury.

TL;DR: Exuberant inflammatory responses within 24 h of admission in patients with COVID-19 may correlate with disease severity, and SARS-CoV-2 infection appears to elicit a sex-based differential immune response.

TL;DR: It is suggested that fgl2 accounts for the fibrin deposition seen in both experimental and human allograft rejection and provide a rationale for targeting fGL2 as adjunctive therapy to treat allografted rejection.

TL;DR: Results in both mice and patients with severe viral hepatitis suggest that virus-induced hfgl2 prothrombinase/fibroleukin expression and the coagulation activity associated with the encoded fgl2 protein play a pivotal role in initiating severe hepatitis.