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Weiming Yan
Researcher at Huazhong University of Science and Technology
Publications - 34
Citations - 932
Weiming Yan is an academic researcher from Huazhong University of Science and Technology. The author has contributed to research in topics: Immune system & Hepatitis. The author has an hindex of 12, co-authored 34 publications receiving 702 citations.
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Journal ArticleDOI
Acute liver failure: mechanisms of immune-mediated liver injury.
TL;DR: This review summarizes current concepts of immune‐mediated liver injury from both clinical studies and animal models and highlights immune responses of ALF from the liver injury perspective, which combines a variety of molecular and cellular mechanisms, particularly, the contribution of cytokines and the innate immune system.
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Increased Killing of Liver NK Cells by Fas/Fas Ligand and NKG2D/NKG2D Ligand Contributes to Hepatocyte Necrosis in Virus-Induced Liver Failure
Yong Zou,Tao Chen,Meifang Han,Hongwu Wang,Weiming Yan,Ge Song,Zeguang Wu,Xiaojing Wang,Chuanlong Zhu,Xiaoping Luo,Qin Ning +10 more
TL;DR: NK cells play a pivotal role in the pathogenesis of FHF and HBV-ACLF, in which process Fas/FasL and NKG2D/NKG 2D ligand pathway contribute to the liver NK cell-mediated hepatocyte injury.
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Longitudinal changes of inflammatory parameters and their correlation with disease severity and outcomes in patients with COVID-19 from Wuhan, China.
Zhilin Zeng,Haijing Yu,Huilong Chen,Weipeng Qi,Liang Chen,Guang Chen,Weiming Yan,Tao Chen,Qin Ning,Meifang Han,Di Wu +10 more
TL;DR: Exuberant inflammatory responses within 24 h of admission in patients with COVID-19 may correlate with disease severity, and SARS-CoV-2 infection appears to elicit a sex-based differential immune response.
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Role of fibrinogen-like protein 2 prothrombinase/fibroleukin in experimental and human allograft rejection.
Qin Ning,Yi Sun,Meifang Han,Li Zhang,Chuanglong Zhu,Weijie Zhang,Hui Guo,Jinwen Li,Weiming Yan,Feili Gong,Zhonghua Chen,William He,Cheryl Koscik,Robert A. Smith,Reginald M. Gorczynski,Gary A. Levy,Xiaoping Luo +16 more
TL;DR: It is suggested that fgl2 accounts for the fibrin deposition seen in both experimental and human allograft rejection and provide a rationale for targeting fGL2 as adjunctive therapy to treat allografted rejection.
Journal ArticleDOI
Fibrinogen-like protein 2 fibroleukin expression and its correlation with disease progression in murine hepatitis virus type 3-induced fulminant hepatitis and in patients with severe viral hepatitis B.
Chuanlong Zhu,Weiming Yan,Fan Zhu,Yong-Fen Zhu,Dong Xi,De-Ying Tian,Gary A. Levy,Xiaoping Luo,Qin Ning +8 more
TL;DR: Results in both mice and patients with severe viral hepatitis suggest that virus-induced hfgl2 prothrombinase/fibroleukin expression and the coagulation activity associated with the encoded fgl2 protein play a pivotal role in initiating severe hepatitis.