https://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(12)61728-0.pdf

Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010

https://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736%2815%2960854-6.pdf?code=lancet-site

Health and climate change: policy responses to protect public health

https://www.who.int/malaria/mpac/mpac_mar2014_wmr2013.pdf

World Malaria Report 2013

https://www.ghdonline.org/uploads/Pyretrhoid_resistance_review-_Ranson_et_al_Trends_in_Parasit_2011.pdf

Pyrethroid resistance in African anopheline mosquitoes: what are the implications for malaria control?

Malaria is a devastating infection caused by protozoa of the genus Plasmodium. Drug resistance is widespread, no new chemical class of antimalarials has been introduced into clinical practice since 1996 and there is a recent rise of parasite strains with reduced sensitivity to the newest drugs. We screened nearly 2 million compounds in GlaxoSmithKline's chemical library for inhibitors of P. falciparum, of which 13,533 were confirmed to inhibit parasite growth by at least 80% at 2 microM concentration. More than 8,000 also showed potent activity against the multidrug resistant strain Dd2. Most (82%) compounds originate from internal company projects and are new to the malaria community. Analyses using historic assay data suggest several novel mechanisms of antimalarial action, such as inhibition of protein kinases and host-pathogen interaction related targets. Chemical structures and associated data are hereby made public to encourage additional drug lead identification efforts and further research into this disease.

https://patentdocs.typepad.com/files/thousands-of-chemical-starting-points-for-antimalarial-lead-identification.pdf

Weltgesundheitsorganisation

Papers

World malaria report