Wenjuan Wang

TL;DR: The results showed that the HcSTP-1 protein engaged in vital suppressive regulatory roles on host immune cells, which might represent a potential molecular target for controlling H. contortus infection in future.

TL;DR: It is demonstrated that HcESPs could inhibit T cell viability, induce cell apoptosis, suppress T cell proliferation and cause cell cycle arrest, and these findings may provide insights into the interaction between ES proteins and key host effector cells, enhancing the understanding of the molecular mechanism underlying parasite immune evasion.

TL;DR: The findings illustrated that rHCA59 could enhance host immune responses by regulating the functions of goat PBMCs and DCs, which would benefit the understanding of HCA59 from parasitic nematodes contributing to the mechanism of parasitic immune evasion.

TL;DR: Results indicated that HcTTR is a novel antagonist against goat IL4 from HcESPs, and this information could improve the understanding of the relationship between host cytokines and parasite infections.

TL;DR: It is found that globin domain‐containing protein (HCGB) and Protein Y75B8A.8 (HC8) from H contortus excretory and secretory products are two binding proteins of IL‐2 in goats and transcriptional analysis revealed that HC8 could block theIL‐2‐activated signalling pathway.