W
Wenzhen Duan
Researcher at Johns Hopkins University School of Medicine
Publications - 88
Citations - 9376
Wenzhen Duan is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Huntingtin & Huntington's disease. The author has an hindex of 46, co-authored 79 publications receiving 8677 citations. Previous affiliations of Wenzhen Duan include Johns Hopkins University & National Institutes of Health.
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Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice
TL;DR: It is suggested that BDNF plays an important role in the regulation of the basal level of neurogenesis in dentate gyrus of adult mice, and that by promoting the survival of newly generated neurons BDNF contributes to the enhancement of Neurogenesis induced by DR.
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Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson's disease.
Wenzhen Duan,Mark P. Mattson +1 more
TL;DR: The striking beneficial effects of DR and 2‐DG in models of PD, when considered in light of recent epidemiological data, suggest that DR may prove beneficial in reducing the incidence of PD in humans.
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Modification of Brain Aging and Neurodegenerative Disorders by Genes, Diet, and Behavior
TL;DR: The recent application of modern methods of molecular and cellular biology to the problem of brain aging is revealing a remarkable capacity within brain cells for adaptation to aging and resistance to disease.
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Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice
Wenzhen Duan,Zhihong Guo,Haiyang Jiang,Melvin Ware,Xiao-Jiang Li,Mark P. Mattson,Mark P. Mattson +6 more
TL;DR: The suppression of the pathogenic processes by DR in HD mice suggests that mutant huntingtin promotes neuronal degeneration by impairing cellular stress resistance, and that the body wasting in HD is driven by the neurodegenerative process.
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Dietary restriction increases the number of newly generated neural cells, and induces BDNF expression, in the dentate gyrus of rats.
TL;DR: It is found that maintenance of adult rats on a DR regimen results in a significant increase in the numbers of newly produced neural cells in the dentate gyrus of the hippocampus, as determined by stereologic analysis of cells labeled with the DNA precursor analog bromodeoxyuridine.