Showing papers by "Wilfried Kuhn published in 1994"
01 Jan 1994
TL;DR: In this article, the influence of dopaminergic treatment on colour vision in Parkinson's patients remains unclear, and the morphological structures responsible for these colour vision disturbances are unknown, but it can be concluded that the dopamine deficiency in Parkinsons disease is not restricted to the basal ganglia but may involve the visual system as well.
Abstract: In recent studies disorders of colour vision in Parkinsonian patients have been demonstrated. Up to now, the influence of dopaminergic treatment on those phenomena remains unclear. We therefore performed a colour vision test (Farnsworth-Munsell 100 Hue Test) in 19 patients with Parkinson's disease before and aater the oral application of the morning dose of L-dopa. The colour discrimination was significantly improved after the ingestion of L-Dopa. There was no different effect of L-Dopa on the blue-yellow or red-green axis of colour vision. The morphological structures responsible for these colour vision disturbances are unknown, but it can be concluded that the dopamine deficiency in Parkinson's disease is not restricted to the basal ganglia but may involve the visual system as well.
74 citations
TL;DR: There is good evidence that patients with Parkinson's disease have respiratory chain dysfunction in their substantia nigra as discussed by the authors, since mitochondrial cytopathies due to enzyme defects in the respiratory cha
Abstract: There is good evidence that patients with Parkinson’s disease have respiratory chain dysfunction in their substantia nigra. Since mitochondrial cytopathies due to enzyme defects in the respiratory cha
25 citations
TL;DR: The colour perception dysfunction indicates that the visual system is affected in HD, and the visual disorder may be related to an imbalance of certain neurotransmitters in thevisual system of HD patients.
Abstract: Colour discrimination and visual contrast perception were investigated in 18 patients with Huntington's disease (HD) and in 18 age- and sex-matched healthy volunteers using the Farnsworth-Munsell 100 Hue test (FM) and stationary contrast targets. The mean total error score (MTES) and the partial scores for the "red-green" and the "blue-yellow" axes in the FM of the patients with HD were significantly elevated as compared to controls (MTES in HD: 113.0 ± 90.8; MTES in controls: 19.2 ± 8.8). The spatial contrast sensitivity in HD patients was normal. The colour perception dysfunction indicates that the visual system is affected in HD. The visual disorder may be related to an imbalance of certain neurotransmitters in the visual system of HD patients. Possible anatomical sites of the dysfunction responsible for colour discrimination abnormalities could be the retinal cone system and/or impaired parvocellular central visual pathways in HD.
13 citations
TL;DR: The case of a 31-year-old woman with this neuro-ophthalmological phenomenon, one of the initial symptoms of established disseminated encephalomyelitis, is reported.
Abstract: Sudden transient attacks of achromatopsia have never been described in the clinical framework of multiple sclerosis. The authors report the case of a 31-year-old woman with this neuro-ophthalmological phenomenon, one of the initial symptoms of established disseminated encephalomyelitis.
2 citations