Recent applications in chiral high performance liquid chromatography: a review.

Supercritical fluid chromatography.

Supercritical fluid chromatography as a tool for enantioselective separation; a review.

Supercritical fluid chromatography (SFC) has developed rapidly in recent years, particularly in the area of enantioseparations. The merits of SFC (e.g., fast analysis speed, wide polarity compatibility, lower cost of the mobile phase and higher column efficiency) would in many cases make it a better choice than high-performance liquid chromatography in drug discovery for the pharmaceutical industry. Packed-column SFC meets the gradual rise in demand for simultaneous chiral and achiral separations, impurity quantitation and direct scaling up from the pharmaceutical purifications achieved in the laboratory, especially for chiral drugs. This review focuses mainly on the latest examples of pharmaceutical separations with chiral stationary phases in SFC for efficient analyses and preparative-scale purifications.

Recent advances in pharmaceutical separations with supercritical fluid chromatography using chiral stationary phases

Ultra-fast high-efficiency enantioseparations by means of a teicoplanin-based chiral stationary phase made on sub-2 μm totally porous silica particles of narrow size distribution.

William B. Holzheuer

Papers

A Comparison of HPLC and SFC Chiral Method Development Screening Approaches for Compounds of Pharmaceutical Interest

Evaluation of Pirkle Stationary Phases in Chiral Method Development Screening for Compounds of Pharmaceutical Interest

Reversed Phase Chiral Method Development Screening for Compounds of Pharmaceutical Interest