W
William L. Clarke
Researcher at University of Virginia
Publications - 147
Citations - 13603
William L. Clarke is an academic researcher from University of Virginia. The author has contributed to research in topics: Hypoglycemia & Diabetes mellitus. The author has an hindex of 58, co-authored 147 publications receiving 12879 citations. Previous affiliations of William L. Clarke include St. Louis Children's Hospital & University of Virginia Health System.
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Journal ArticleDOI
Evaluating Clinical Accuracy of Systems for Self-Monitoring of Blood Glucose
TL;DR: An error grid analysis (EGA) is developed, which describes the clinical accuracy of SMBG systems over the entire range of blood glucose values, taking into account the absolute value of the system-generated glucose value, the relative difference between these two values, and the clinical significance of this difference.
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Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence.
Doris A. Stoffers,Noah T. Zinkin,Violeta Stanojevic,William L. Clarke,Joel F. Habener,Joel F. Habener +5 more
TL;DR: It is likely that this autosomal recessive mutation is the cause of the pancreatic agenesis phenotype in this patient, and IPF1 appears to be a critical regulator of pancreas development in humans as well as mice.
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Early-onset type-II diabetes mellitus (MODY4) linked to IPF1.
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Reduced Awareness of Hypoglycemia in Adults With IDDM: A prospective study of hypoglycemic frequency and associated symptoms
William L. Clarke,Daniel J. Cox,Linda Gonder-Frederick,Diana M Julian,David G. Schlundt,William H. Polonsky +5 more
TL;DR: Reduced-awareness individuals may benefit from interventions designed to teach them to recognize all of their potential early warning symptoms, and both disease duration and level of glucose control explains their reduced awareness of hypoglycemia.
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Evaluating the Accuracy of Continuous Glucose-Monitoring Sensors: Continuous glucose–error grid analysis illustrated by TheraSense Freestyle Navigator data
TL;DR: CG-EGA is introduced as a method of evaluating the accuracy of continuous glucose-monitoring sensors in terms of both accurate blood glucose values and accurate direction and rate of BG fluctuations and illustrated with data from the TheraSense Freestyle Navigator.