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William O. Cepurna
Researcher at Oregon Health & Science University
Publications - 77
Citations - 2668
William O. Cepurna is an academic researcher from Oregon Health & Science University. The author has contributed to research in topics: Optic nerve & Glaucoma. The author has an hindex of 25, co-authored 74 publications receiving 2384 citations.
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Journal ArticleDOI
Understanding mechanisms of pressure-induced optic nerve damage.
TL;DR: Clear evidence is beginning to uncover that abnormalities in the optic nerve head and retina may influence relative susceptibility to IOP and explain progressive optic nerve damage and visual field loss, in spite of apparent, clinically adequate IOP control.
Journal ArticleDOI
Global changes in optic nerve head gene expression after exposure to elevated intraocular pressure in a rat glaucoma model.
TL;DR: In the ONH, pressure-induced injury results in cell proliferation and dramatically altered gene expression, suggesting that further array studies may identify initial, and potentially injurious, altered processes.
Journal ArticleDOI
Selective Ganglion Cell Functional Loss in Rats with Experimental Glaucoma
Brad Fortune,Bang V. Bui,John C. Morrison,Elaine C. Johnson,J. Dong,William O. Cepurna,Li Jun Jia,Stacey Barber,George A. Cioffi +8 more
TL;DR: In rodent models of experimental glaucoma, lower levels of chronically elevated IOP may be more relevant to human primary chronic glAUcoma than the highest IOP levels, which resulted in nonselective functional loss.
Journal Article
Effect of General Anesthetics on IOP in Rats with Experimental Aqueous Outflow Obstruction
TL;DR: Measurement of IOP in awake animals provides the most accurate documentation of pressure histories for rat glaucoma model studies and increased the interanimal variability in IOPs.
Journal Article
Patterns of intraocular pressure elevation after aqueous humor outflow obstruction in rats.
TL;DR: Episcleral vein injection of hypertonic saline is more likely to increase diural intraocular pressure (IOP) during the dark phase than the light, consistent with aqueous outflow obstruction superimposed on a circadian rhythm of aqueously humor production.