W
William R. Morton
Researcher at University of Washington
Publications - 85
Citations - 4270
William R. Morton is an academic researcher from University of Washington. The author has contributed to research in topics: Virus & Simian immunodeficiency virus. The author has an hindex of 34, co-authored 85 publications receiving 4218 citations.
Papers
More filters
Journal ArticleDOI
Protection of macaques against SIV infection by subunit vaccines of SIV envelope glycoprotein gp160.
Hu Shiu-Lok,Kraig Abrams,Glen N. Barber,Paricia Moran,Joyce M. Zarling,Alphonse J. Langlois,La Rene Kuller,William R. Morton,Raoul E. Benveniste +8 more
TL;DR: Results indicate that immunization with viral envelope antigens alone is sufficient to elicit protective immunity against a primate immunodeficiency virus.
Journal ArticleDOI
Effectiveness of Postinoculation (R)-9-(2-Phosphonylmethoxypropyl)Adenine Treatment for Prevention of Persistent Simian Immunodeficiency Virus SIVmne Infection Depends Critically on Timing of Initiation and Duration of Treatment
Che-Chung Tsai,Peter Emau,Kathryn E. Follis,Thomas W. Beck,Raoul E. Benveniste,Norbert Bischofberger,Jeffrey D. Lifson,William R. Morton +7 more
TL;DR: The results clearly show that both the time between virus exposure and initiation of PMPA treatment as well as the duration of treatment are crucial factors for prevention of acute SIV infection in the macaque model.
Journal ArticleDOI
Cyanovirin-N Inhibits AIDS Virus Infections in Vaginal Transmission Models
Che Chung Tsai,Peter Emau,Yonghou Jiang,Michael B. Agy,Robin J. Shattock,Ann Schmidt,William R. Morton,Kirk R. Gustafson,Michael R. Boyd +8 more
TL;DR: It is shown that recombinant CV-N effectively blocks HIV-1(Ba-L) infection of human ectocervical explants and in vivo efficacy ofCV-N gel in a vaginal challenge model is demonstrated, suggesting that CV-n is a good candidate for testing in humans as an anti-HIV topical microbicide.
Journal ArticleDOI
Cyanovirin-N gel as a topical microbicide prevents rectal transmission of SHIV89.6P in macaques.
Che Chung Tsai,Peter Emau,Yonghou Jiang,Baoping Tian,William R. Morton,Kirk R. Gustafson,Michael R. Boyd +6 more
TL;DR: It is indicated that CV-N gel as a topical microbicide can prevent rectal transmission of SHIV in macaques, and these studies encourage clinical evaluation ofCV-N as a Topical Microbicide to prevent sexual transmission of HIV in humans.
Journal ArticleDOI
Infection of Macaca nemestrina by human immunodeficiency virus type-1
Michael B. Agy,Lyn R. Frumkin,Lawrence Corey,Robert W. Coombs,Steven M. Wolinsky,James K. Koehler,William R. Morton,Michael G. Katze +7 more
TL;DR: Macaca nemestrina is an animal model of HIV-1 infections that provides opportunities for evaluating the pathogenesis of acute HIV- 1 replication and candidate vaccines and therapies.