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William T. Greenough
Researcher at University of Illinois at Urbana–Champaign
Publications - 200
Citations - 30207
William T. Greenough is an academic researcher from University of Illinois at Urbana–Champaign. The author has contributed to research in topics: Synapse & Dendritic spine. The author has an hindex of 93, co-authored 200 publications receiving 29230 citations. Previous affiliations of William T. Greenough include University of Pittsburgh & Memorial University of Newfoundland.
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Journal ArticleDOI
Experience and brain development.
TL;DR: A new categorization scheme based upon the type of information stored and the brain mechanisms that appear to be involved in storing it is proposed, which offers a new view more in accord with neural mechanisms than were terms like "critical" or "sensitive period."
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Learning causes synaptogenesis, whereas motor activity causes angiogenesis, in cerebellar cortex of adult rats.
James E. Black,Krystyna R. Isaacs,Brenda J. Anderson,Adriana A. Alcantara,William T. Greenough +4 more
TL;DR: The role of the cerebellar cortex in motor learning was investigated by comparing the paramedian lobule of adult rats given difficult acrobatic training to that of rats that had been given extensive physical exercise or had been inactive.
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Abnormal dendritic spines in fragile X knockout mice: maturation and pruning deficits.
Thomas A. Comery,Jennifer B. Harris,Patrick Willems,Ben A. Oostra,Scott A. Irwin,Ivan Jeanne Weiler,William T. Greenough +6 more
TL;DR: Dendritic spines in Golgi-impregnated cerebral cortex of transgenic fragile X gene (Fmr1) knockout mice that lack expression of the protein were longer than those in wild-type mice and were often thin and tortuous, paralleling the human syndrome and suggesting that FMRP expression is required for normal spine morphological development.
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Abnormal dendritic spine characteristics in the temporal and visual cortices of patients with fragile-X syndrome: a quantitative examination
Scott A. Irwin,Biraju Patel,Madhuri Idupulapati,Jennifer B. Harris,Ralph A. Crisostomo,Brian P. Larsen,R. Frank Kooy,Patrick Willems,Patrick Cras,Piotr B. Kozlowski,Rodney A. Swain,Ivan Jeanne Weiler,William T. Greenough +12 more
TL;DR: Qualitative examination of human brain autopsy material has shown that fragile-X patients exhibit abnormal dendritic spine lengths and shapes on parieto-occipital neocortical pyramidal cells, which may suggest a global failure of normal dendrites maturation and or pruning during development that persists throughout adulthood.
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Fragile X Mental Retardation Protein is Translated near Synapses in Response to Neurotransmitter Activation
Ivan Jeanne Weiler,Scott A. Irwin,Anna Y. Klintsova,Corinne Spencer,Anthony D. Brazelton,Kevin Miyashiro,Thomas A. Comery,Bindu Patel,James Eberwine,William T. Greenough +9 more
TL;DR: It is suggested that rapid production of FMRP near synapses in response to activation may be important for normal maturation of synaptic connections.