Showing papers by "William W. Busse published in 1973"

Failure of catecholamines to inhibit epidermal mitosis in vitro.

Abstract: Skin samples were obtained from the forearm and leg of normal volunteers and patients with atopic eczema. The samples were incubated with 3 H-thymidine, and the radioactivity incorporated was measured at 48 hours. Isoproterenol, epinephrine, or norepinephrine was added in concentration of 10 −5 M to 10 −10 M. There was inhibition of deoxyribonuclear acid (DNA) synthesis in control samples with the catecholamines. In contrast, the catecholamines failed to inhibit DNA synthesis in the skin from patients with atopic eczema. It was concluded that inhibition of DNA synthesis is a beta adrenergic effect, and the cells of patients with atopic eczema are insensitive to beta stimulation.

Prolonged retention of radioactivity following perfusion lung scan in asthmatic patients.

Abstract: Abnormalities of the perfusion lung scan during acute asthmatic episodes are well known. Prolongation of the biological half-life of /sup 131/I- ndacroaggregated albumin (MAA) was not previously reported. Evaluation of the biological clearance of MAA from the lungs in 14 patients with asthma (7 males and 7 females) showed substantial prolongation in 12 patients. This phenomenon is not specific to asthma but was observed in patients taking steroids, immunosuppressive therapy, viral pneumonia, and chronic interstitial lung disease. (auth)