Wolfgang Löscher

TL;DR: A comparison of the pharmacology of chronic models with models of acute (reactive or provoked) seizures in previously healthy (non-epileptic) animals demonstrates that drug testing in chronic models of epilepsy yields data which are more predictive of clinical efficacy and adverse effects, so that chronic models should be used relatively early in drug development to minimize false positives.

TL;DR: PTZ might be suitable for predicting efficacy against myoclonic petit mal seizures in humans, but certainly not to predict efficacy against absence seizures, and various factors delineated in this study should be rigidly controlled in experimental situations involving assay of anticonvulsant agents.

TL;DR: Factors other than sex, age, diet, climate and circadian rhythms, which are generally known are delineated in this study to reduce the variability among estimates of anticonvulsant activity.

TL;DR: Improved accuracy in the diagnosis of CTS is revealed with the Delta CSA compared with the accuracy of the diagnosis determined with the CSAc, which is smaller than that in patients and in asymptomatic wrists.

TL;DR: The contribution of gastrocnemius to plantar flexor torque is at least 40% of the total torque in the straight leg position, while investigating the activation of the gastrocNemius muscle at standardised non-optimal lengths.