Compositions pour la teinture des fibres kératiniques contenant des diamino pyrazoles, procédé de teinture, nouveaux diamino pyrazoles et leur procédé de préparation

The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

Modulators of atp-binding cassette transporters

A hair dye composition containing a triazene dissociative direct dye represented by general formula (1): A-N=N-NH-B (1) wherein A and B are each a monocyclic or a bicyclic aromatic heterocyclic group that may have a substituent or a monocyclic or a bicyclic aryl group that may have a substituent and contain none of a carboxy group, a sulfo group and a quaternary ammonium group; and A and B each bind to a triazene-1,3-diyl group represented by -N=N-NH- via a carbon atom within A and B each. A and B may be the same or different.

Hair-dye composition

The subject matter of the present invention is directed to a process for producing 4,5-diaminopyrazole derivatives of the general formula (I) ##STR1## where R1 and R2 independently designate hydrogen, a C1 - to C6 -alkyl radical or a C2 - to C4 -hydroxyalkyl radical, which can be used as dye precursors, for example for hair dyes, and to new pyrazole derivatives. When using the process according to the invention good yields of isomer-pure 4,5-diaminopyrazole derivatives of general formula (I) can be obtained.

Process for the synthesis of 4,5-diaminopyrazole derivatives useful for dyeing hair

The present invention relates to novel antibodies capable of binding specifically to the human insulin-like growth factor I receptor IGF-IR and/or capable of specifically inhibiting the tyrosine kinase activity of said IGF-IR, especially monoclonal antibodies of murine, chimeric and humanized origin, as well as the amino acid and nucleic acid sequences coding for these antibodies. The invention likewise comprises the use of these antibodies as a medicament for the prophylactic and/or therapeutic treatment of cancers overexpressing IGF-IR or any pathology connected with the overexpression of said receptor as well as in processes or kits for diagnosis of illnesses connected with the overexpression of the IGF-IR. The invention finally comprises products and/or compositions comprising such antibodies in combination with anti-EGFR antibodies and/or anti-VEGF antibodies and/or antibodies directed against other growth factors involved in tumor progression or metastasis and/or compounds and/or anti-cancer agents or agents conjugated with toxins and their use for the prevention and/or the treatment of certain cancers.

Novel anti-igf-ir antibodies and uses thereof

Agents for the oxidative dyeing of hair based on a developer-coupler combination containing as the developer a 4,5-diaminopyrazole derivative of general formula (I) in which R1 is halogen, C?1?-C4 alkyl, C1-C4 alkoxy and R?2? is hydrogen, C?1?-C4 alkyl, C2-C4 hydroxyalkyl, or their physiologically acceptable, water-soluble salts, and novel 4,5-diaminopyrazole derivatives.

Oxidation hair dye containing 4,5-diaminopyrazole derivatives and novel 4,5-diaminopyrazole derivatives and process for their production

Mittel zur oxidativen Farbung von Haaren auf der Basis einer Entwicklersubstanz-Kupplersubstanz-Kombination, welches als Entwicklersubstanz ein Aminopyrazolderivat der allgemeinen Formel (I), in der R Wasserstoff oder (C1-C4)-Alkyl bedeutet und n 2 oder 3 ist, oder dessen physiologisch vertragliche wasserlosliche Salze enthalt, sowie neue Pyrazolderivate. Die Aminopyrazolderivate der Formel (I) sind physiologisch gut vertraglich, einfach herzustellen und farben mit ublichen Kupplersubstanzen das Haar in brillanten roten Farbtonen mit einer hohen Farbtiefe.

Haarfaerbemittel mit einem gehalt an aminopyrazolderivaten sowie neue pyrazolderivate

The present invention relates to a process for producing 4,5-diamino pyrazole derivatives of general formula (I) in which R1 and R2 are mutually independently hydrogen, a C1 to C6 alkyl residue or a C2 to C4 hydroxy alkyl residue, which may be used as colorant pre-products, e.g. for hair colorants, and novel pyrzole derivatives. The use of the process of the invention makes it possible to obtain 4,5-diamino pyrazole derivatives of general formula (I) without isomers and with good yields.

Process for producing 4,5-diamino pyrazole derivatives, their use for colouring hair and novel pyrazole derivatives

Oxidative hair dye composition comprises a coupler substance (II) and a developer substance consisting of a 3,4,5-triaminopyrazole compound of formula (I), or physiologically compatible, water-soluble salts of these. R1 = H, 1-4 C alkyl or 2-4 C hydroxyalkyl; and R2 = H, 1-4 C alkyl or 2-4 C hydroxyalkyl. The compounds (I) are new.

Wolfgang R. Balzer

Papers

Oxidation hair dye containing 4,5-diaminopyrazole derivatives and novel 4,5-diaminopyrazole derivatives and process for their production

Haarfaerbemittel mit einem gehalt an aminopyrazolderivaten sowie neue pyrazolderivate

Process for producing 4,5-diamino pyrazole derivatives, their use for colouring hair and novel pyrazole derivatives

Oxidative hair dye composition

Process for the synthesis of 4,5-diaminopyrazole derivatives useful for dyeing hair