Showing papers by "Wulf Dietrich published in 2007"
TL;DR: The risk of hypersensitivity reactions is low after primary exposure to aprotinin, but this risk after reexposure reaches a maximum between the fourth day and the 30th day after previous exposure and declines considerably after 6 months.
67 citations
TL;DR: Overall, autologous blood donation reduced the incidence of allogeneic blood transfusion from 48 to 13% during hospitalization, and it is shown that diagnosis adjusted autologOUS blood donation is cost-effective.
Abstract: The risk of transfusion of allogeneic blood products on outcome is well documented. Autologous blood donation prior to elective cardiac surgery has repeatedly shown to be an effective practice to reduce the exposure to allogeneic blood, but was criticized because of the alleged high costs. We analyzed the data of 4878 patients undergoing elective open-heart surgery, in whom 18% underwent autologous donation. Overall, autologous blood donation reduced the incidence of allogeneic blood transfusion from 48 to 13% during hospitalization. Additionally, it is shown that diagnosis adjusted autologous blood donation is cost-effective. The higher the probability of transfusion the better is efficacy and cost-effectiveness of predonation. Cardiac surgery is a high-transfusion area, thus, it offers ideal conditions for autologous donation. Autologous blood donation still remains a promising and cost-effective alternative to reduce allogeneic blood transfusion in elective cardiac surgery.
2 citations