X
Xian-Zhi Li
Researcher at Health Canada
Publications - 8
Citations - 2920
Xian-Zhi Li is an academic researcher from Health Canada. The author has contributed to research in topics: Efflux & Drug resistance. The author has an hindex of 5, co-authored 5 publications receiving 2518 citations. Previous affiliations of Xian-Zhi Li include University of California.
Papers
More filters
Journal ArticleDOI
Efflux-Mediated Drug Resistance in Bacteria
Xian-Zhi Li,Hiroshi Nikaido +1 more
TL;DR: Fluoroquinolones and β-lactams of the latest generations are likely to select for overproduction mutants of these pumps and make the bacteria resistant in one step to practically all classes of antibacterial agents.
Journal ArticleDOI
The Challenge of Efflux-Mediated Antibiotic Resistance in Gram-Negative Bacteria
TL;DR: This article highlights the recent progress obtained for organisms of clinical significance, together with methodological considerations for the characterization of MDR pumps, with particular focus on AcrAB-TolC and Mex pumps.
Journal ArticleDOI
Efflux-mediated drug resistance in bacteria: an update.
Xian-Zhi Li,Hiroshi Nikaido +1 more
TL;DR: The multifaceted implications of drug efflux transporters warrant novel strategies to combat multidrug resistance in bacteria.
Book ChapterDOI
Antimicrobial Drug Efflux Pumps in Pseudomonas aeruginosa
Xian-Zhi Li,Patrick Plésiat +1 more
TL;DR: This chapter provides an up-to-date overview of antimicrobial drug efflux pumps in P. aeruginosa with a focus on their substrates, regulation, inhibition, and clinical significance.
Book ChapterDOI
Antimicrobial Drug Efflux Pumps in Escherichia coli
Xian-Zhi Li,Hiroshi Nikaido +1 more
TL;DR: This chapter provides an updated overview of more than 20 individual efflux systems/pumps of various families in E. coli with a focus on their substrate profiles, clinical relevance, and expression-based regulation.