Xiao Lin

TL;DR: The epidemiology of osteoporotic fractures in the People’s Republic of China is summarized, including the epidemiological measures and pharmacological treatments focusing on preventive methods and the management of osteopsorosis, which consist of basic measures and Pharmacological treatments.

TL;DR: The data indicate an intracellular role for VCAN in VSMCs, which participates in hyperglycemia-induced calcification/senescence via modulation of mitochondrial function inVSMCs.

TL;DR: It is found that both osteogenic differentiation and senescence of vascular smooth muscle cells (VSMCs) were attenuated by MT in a MT membrane receptor‐dependent manner and exosomes from MT‐treated VSMCs could attenuate vascular calcification and ageing in a paracrine manner through an exosomal miR‐204/miR‐211.

TL;DR: This study reveals a new mechanism by which hypoxic papillary thyroid cancer cells increase angiogenesis via exosomal miR-21-5p/TGFBI and microRNAs involved in the interaction of cancer and para-carcinoma cells through the exosome-to-exosomal regulatory pathway.

TL;DR: It is shown that oestrogen inhibits the osteoblastic differentiation of vascular smooth muscle cells (VSMCs) in vitro and arterial calcification in vivo by promoting autophagy through the ERα signalling pathway, which provides new insights into the mechanism by which oestrogens contributes to vascular calcificationIn vitro and in vivo.