In the past few years, numerous studies have demonstrated the great potential of nano particles of metal-organic frameworks (nanoMOFs) at the preclinical level for biomedical applications. Many of them were reported very recently based on their bioactive composition, anticancer application, or from a general drug delivery/theranostic perspective. In this review, the authors aim at providing a global view of the studies that evaluated MOFs' biomedical applications at the preclinical stage, when in vivo tests are described either for pharmacological applications or for toxicity evaluation. The authors first describe the current surface engineering approaches that are crucial to understand the in vivo behavior of the nanoMOFs. Finally, after a detailed and comprehensive analysis of the in vivo studies reported with MOFs so far, and considering the general evolution of the drug delivery science, the authors suggest new directions for future research in the use of nanoMOFs for biomedical applications.

Nanoparticles of Metal-Organic Frameworks: On the Road to In Vivo Efficacy in Biomedicine.

https://pubs.rsc.org/en/content/articlepdf/2018/cc/c7cc07549a

The antibacterial activity of polyoxometalates: structures, antibiotic effects and future perspectives.

Green synthesis of metal–organic frameworks: A state-of-the-art review of potential environmental and medical applications

Readily available cyclodextrins (CDs) with an inherent hydrophobic internal cavity and hydrophilic external surface are macrocyclic entities that display a combination of molecular recognition and complexation properties with vital implications for host–guest supramolecular chemistry. While the host–guest chemistry of CDs has been widely recognized and led to their exploitation in a variety of important functions over the last five decades, these naturally occurring macrocyclic systems have emerged only recently as promising macrocyclic molecules to fabricate environmentally benign functional nanomaterials. This review surveys the development in the field paying special attention to the synthesis and emerging uses of various unmodified CD–metal complexes and CD–inorganic nanoparticle systems and identifies possible future directions. The association of a hydrophobic cavity of CDs with metal ions or various inorganic nanoparticles is a very appealing strategy for controlling the inorganic subunits properti...

Interactions of Native Cyclodextrins with Metal Ions and Inorganic Nanoparticles: Fertile Landscape for Chemistry and Materials Science.

One of the more recent and promising domains of the application of Metal Organic Frameworks (MOFs) is the biomedical one. To fulfil the keystone requirements of bioapplications, i.e. biosafety and activity, endogenous and/or bioactive motifs (cations, organic ligands or both) have been successfully used as constitutive building blocks to construct Metal Biomolecule Frameworks (also known as bioMOFs). This review highlights the latest advances in 3D bioMOF structures, from their synthesis to their biorelated activities in different biorelated areas including drug delivery, imaging, and sensing, classifying them by the nature of the active component.

Metal organic frameworks based on bioactive components.

Self-assembly of multiple components into well-defined and predictable structures remains one of the foremost challenges in chemistry. Here, upon subtle ligand variation, we reported on the assembly of three new polyoxometalate-based organic–inorganic hybrid compounds with different helical channel, [Ag3(H2pyttz-I)2][PMo12O40] (1), [Ag6(H2pyttz-II)4][CoW12O40]·2H2O (2), and [Ag7(Hpyttz-II)3(H2pyttz-II)][GeW12O40]·7H2O (3) (H2pyttz-I/II = 4-/3-pyrid-5-(1H-1,2,4-triazol-3-yl)-1,2,4-triazolyl, POM = polyoxometalates). X-ray diffraction analysis shows that compound 1 is constructed by “butterfly-like” Ag5(H2pyttz-I)2 subunits and POMs clusters, which are assembled into close helical channels impregnated with the components selves. Both compounds 2 and 3 are constructed by “paddle-wheel like” Ag4(H2pyttz-II)4 motifs and POMs clusters, which bring into being the larger helical channels (10.5% and 12.5% of the cell volume, respectively). Note that the only difference in compounds 2 and 3 is that the former conta...

Xiao-Ning Yang

Papers

Assembly of Polyoxometalate-Based Hybrids with Different Helical Channels upon Subtle Ligand Variation

Study on a new cyclodextrin based metal–organic framework with chiral helices

Synthesis and structure of new carbohydrate metal–organic frameworks and inclusion complexes

Study on the Keggin zinctungstates based hybrid compound with like DNA spiral chain

Assembly of an unprecedented metal-pipemidic acid complex modifying octamolybdates containing like DNA spiral chain