Xiaodong Ma

TL;DR: The chemical structure and the therapeutic versatility of resveratrol derivatives are summarized to provide the related structure activity relationship reference for their practical applications.

TL;DR: The data showed that dioscin is a novel and potent FXR agonist to suppress inflammation and oxidative stress against Dox-induced nephrotoxicity.

TL;DR: This review on the small-molecule EGFR T790M inhibitors, along with their discovery strategies, will assist in the design of future T790m-containing EGFR inhibitors with high levels of selectivity over WT EGFR, broad kinase selectivity, and desirable physicochemical properties.

TL;DR: The neuroprotective effects of PCr in vitro and in vivo rely on normalizing mitochondrial function and reducing oxidative stress via Akt mediated Nrf2/HO‐1 pathway, suggesting that PCr may be a novel therapeutic candidate for the treatment of diabetes‐associated neurodegenerative diseases.

TL;DR: Dioscin showed protective effects against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, renal fibrosis, lipid metabolism and inflammation, which should be considered as one candidate to treat renal injury in the future.