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Xiaohu Zhang
Researcher at Soochow University (Suzhou)
Publications - 78
Citations - 1306
Xiaohu Zhang is an academic researcher from Soochow University (Suzhou). The author has contributed to research in topics: Smoothened & Adenosine receptor. The author has an hindex of 22, co-authored 70 publications receiving 1029 citations. Previous affiliations of Xiaohu Zhang include Rutgers University & Neurocrine Biosciences.
Papers
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Journal ArticleDOI
Discovery of potent necroptosis inhibitors targeting RIPK1 kinase activity for the treatment of inflammatory disorder and cancer metastasis
Jue Hou,Jie Ju,Zili Zhang,Cong Zhao,Zhanhui Li,Jiyue Zheng,Tian Sheng,Hongjian Zhang,Linkun Hu,Xiaoliang Yu,Wei Zhang,Yangxin Li,Meng Wu,Haikuo Ma,Xiaohu Zhang,Sudan He +15 more
TL;DR: This study demonstrates that PK68 is a potent and selective inhibitor of RIPK1 and also highlights its great potential for use in the treatment of inflammatory disorders and cancer metastasis.
Journal ArticleDOI
Anti-inflammatory effects of glaucocalyxin B in microglia cells.
Ping Gan,Li Zhang,Yanke Chen,Yu Zhang,Fali Zhang,Xiang Zhou,Xiaohu Zhang,Bo Gao,Xuechu Zhen,Jian Zhang,Long Tai Zheng +10 more
TL;DR: It is demonstrated that the GLB possesses anti-nueroinflammatory activity, and might serve as a potential therapeutic agent for treating neuroinflammatory diseases.
Patent
Substituted pyrimidines as adenosine receptor antagonists
TL;DR: In this article, the authors defined a class of compounds of formula (I) including pharmaceutically acceptable salts, esters, solvates and stereoisomers thereof, R1, R2 and R3.
Journal ArticleDOI
2-Amino-N-pyrimidin-4-ylacetamides as A2A receptor antagonists: 1. Structure-activity relationships and optimization of heterocyclic substituents.
Deborah H. Slee,Yongsheng Chen,Xiaohu Zhang,Manisha Moorjani,Marion Lanier,Emily Lin,Jaimie K. Rueter,John P. Williams,Sandra M. Lechner,Stacy Markison,Siobhan Malany,Mark Santos,Raymond S. Gross,Kayvon Jalali,Yang Sai,Zhiyang Zuo,Chun Yang,Julio C. Castro-Palomino,María I. Crespo,Maria Prat,Silvia Gual,Jose-Luis Diaz,John Saunders +22 more
TL;DR: The synthesis and SAR of a range of novel heterocyclic systems are described and the successful identification of a replacement for the unsubstituted furan moiety with a methylfuran or thiazole moiety is identified while maintaining potency and selectivity.
Journal ArticleDOI
The oncometabolite 2-hydroxyglutarate inhibits microglial activation via the AMPK/mTOR/NF-κB pathway
Chaojun Han,Jiyue Zheng,Lin Sun,Huicui Yang,Zhong-qiang Cao,Xiaohu Zhang,Long Tai Zheng,Xuechu Zhen +7 more
TL;DR: Results show that oncometabolite 2HG inhibits microglial activation through affecting AMPK/mTOR/NF-κB signaling pathway and provide evidence that on cometabolic product 2-hydroxyglutarate (2HG) may regulate glioma development via modulating microglia activation in tumor microenvironment.