The invention discloses a preparation method of a benzopyran compound and application of protecting against pulmonary fibrosis. The structural formula of the benzopyran compound refers to the Specification, wherein R1 is one selected from H, C1-C4 alkyl and residual groups of various amino acids after removing amino parts, R2 is one selected from H, C1-C4 alkyl and residual groups of various amino acids after removing amino parts, R3 is one selected from H abd C1-C4 alkyl and residual groups of various amino acids after removing amino parts, and n is any integer of 1-4. The benzopyran compound is obtained from a fermentation liquid of Streptomyces xiamenensis (CGMCC No.5675) by extraction, separation and purification. The Streptomyces xiamenensis extract derivative disclosed by the invention has higher property of inhibiting the proliferation and activity of health human lung fibroblasts, and can be used for preparing anti-pulmonary fibrosis drugs.

Preparation method of benzopyran compound and application of protecting against pulmonary fibrosis

The invention discloses a pancreas cancer prevention use of polycyclic fused macrocyclic lactam compounds. The structural formula of the polycyclic fused macrocyclic lactam compounds is shown in the description; and in the formula, R1 is OCH3 or H, R2 is Cl or OH, and R3 is OCH3 or H. The polycyclic fused macrocyclic lactam compounds are separated through separating and purifying a fermentation liquid of Streptomyces xiamenensis CGMCC No.4.3534 from mangrove soil. Prepared ikarugamycin and derivatives thereof can inhibit proliferation and vitality of human pancreas cancer cells, and can be used to prepare pancreas cancer prevention drugs.

Pancreas cancer prevention use of polycyclic fused macrocyclic lactam compounds

The invention relates to the technical field of medicines, in particular to application of a benzopyran alkaloid. The application of the benzopyran alkaloid to the preparation of medicines for restraining formation of hypertrophic scars is involved; the benzopyran alkaloid has the structural formula which is shown in specifications; and the benzopyran alkaloid can restrain proliferation and viability of normal human skin fibroblast, block the adhesion of normal human skin fibroblast (NHSF) and human mononuclear/macrophage (THP-1), and weaken contractility of the normal human skin fibroblast (NHSF).

徐俊

Papers

Preparation method of benzopyran compound and application of protecting against pulmonary fibrosis

Pancreas cancer prevention use of polycyclic fused macrocyclic lactam compounds

Application of benzopyran alkaloid