Xue Bai

TL;DR: It is found that nicotine resulted in larger atherosclerotic plaques and secretion of inflammatory cytokines in ApoE−/− mice fed with a high-fat diet (HFD) and pyroptosis is likely a cellular mechanism for the pro-atherosclerosis property of nicotine.

TL;DR: It is suggested that melatonin prevents endothelial cell pyroptosis via MEG3/miR‐223/NLRP3 axis in atherosclerosis, and therefore, melatonin replacement might be considered a new strategy for protecting endothelium against pyroPTosis, thereby for the treatment of Atherosclerosis associated with pyroaptosis.

TL;DR: The results showed that induction of autophagy lead to down-regulation of miR-183 in colorectal cancer cells, and that over-expression of UVRAG rescued autophagic activity and induced apoptosis in presence of mi R-183.

TL;DR: This study deciphered the essential role of Lin28B in the pathogenesis of EMT, unraveled a novel mechanism that miR-26a is a modulator of let-7d, and defined the miRNAs network involved in IPF, which may have implications for developing new strategies for pulmonary fibrosis.

TL;DR: The data uncovered the novel molecular interaction between miR-519d and MMP3, indicating a therapeutic strategy of miR -519d for BC.