BIOE 402. Medical Technology Assessment. 2 or 3 hours. Bioentrepreneur course. Assessment of medical technology in the context of commercialization. Objectives, competition, market share, funding, pricing, manufacturing, growth, and intellectual property; many issues unique to biomedical products. Course Information: 2 undergraduate hours. 3 graduate hours. Prerequisite(s): Junior standing or above and consent of the instructor.

“Bioinformatics” 특집을 내면서

https://www.pnas.org/content/pnas/90/5/1635.full.pdf

Supramolecular chemistry.

I-CYP binding sites) was determinedafter 24 hours of isoproterenol treatment and ex-pressed as the percentage of receptor number as-sessed in nonstimulated cells. Where necessary,MG132 (20 mM) or lactacystin (20 mM) mixed inserum-free media was added to cells 1 hour beforestimulation.16. P. van Kerkhof, R. Govers, C. M. Alves dos Santos, G. J.Strous,

https://cml.harvard.edu/assets/science294_1313.pdf

Logic Gates and Computation from Assembled Nanowire Building Blocks

This survey presents various methods of improving the overall estimation quality in the class of extended state observers (ESO), which estimate not only the conventional states of the system, but the acting disturbance as well. This type of observers is crucial in forming the active disturbance rejection control structure (ADRC), where the precision of online perturbation reconstruction and cancellation directly influences the robustness of the closed-loop control system. Various aspects of the observer-based disturbance estimation/rejection loop are covered by this work and divided into three categories, related with observer: structure, tuning, and working conditions. The survey is dedicated to researchers and practitioners who are interested in increasing the efficiency of their ADRC-based governing schemes.

Survey on methods of increasing the efficiency of extended state disturbance observers.

A survey on applications and variants of the cuckoo search algorithm

The vast parallelism, exceptional energy efficiency and extraordinary information density inherent in DNA molecules are being explored for computing, data storage and cryptography. DNA cryptography is a new field of cryptography arising with the research of DNA computing in recent years. In this paper, an encryption scheme is designed by using the technologies of DNA synthesis, PCR amplification and DNA digital coding as well as the theory of traditional cryptography. By applying the special function of primers to PCR amplification, the primers and coding mode are used as the key of the scheme. The traditional encryption method and DNA digital coding are used to preprocess to the plaintext, which can effectively prevent attack from a possible word as PCR primers. Biological difficult issues and cryptography computing difficulties provide a double security safeguards for the scheme. And the security analysis shows that the encryption scheme has high confidential strength. To demonstrate the performance, we present an interesting example to encode and decode message just between specific two persons using the proposed scheme.

An encryption scheme using DNA technology

Encoding and processing information in DNA-, RNA- and other biomolecule-based devices is an important requirement for DNA based computing with potentially important applications. To make DNA computing more reliable, much work has focused on designing the good DNA sequences. However, this is a bothersome task as encoding problem is an NP problem. In this paper, a new methodology based on the IWO algorithm is developed to optimize encoding sequences. Firstly, the mathematics models of constrained objective optimization design for encoding problems based on the thermodynamic criteria are set up. Then, a modified IWO method is developed by defining the colonizing behavior of weeds to overcome the obstacles of the original IWO algorithm, which cannot be applied to discrete problems directly. The experimental results show that the proposed method is effective and convenient for the user to design and select effective DNA sequences in silicon for controllable DNA computing.

Application of a novel IWO to the design of encoding sequences for DNA computing

Based on the Feistel network and dynamic deoxyribonucleic acid (DNA) encoding technology, an image encryption method is proposed using the “permutation-diffusion-scrambling” structure. First, the SHA-3 algorithm is used to calculate the hash value of the plaintext image as the initial value of the hyperchaotic system, and the chaos-generated sequence is used to generate the Hill cipher matrix to replace the image pixel. Second, the DNA sequence operation is used as the F function of the Feistel network. The DNA sequence database is used as the key K of Feistel network, and the image pixel value diffusion is realized by the Feistel network. Finally, further diffusion is carried out through the ciphertext feedback and through the ciphertext confusion and diffusion of three rounds of “chaotic scrambling-DNA encoding-Feistel transformation-DNA decoding,” making the ciphertext more random and resistant to attacks and ensuring that the encrypted ciphertext is more secure. The experimental results show that the proposed method can effectively encrypt the image and has prominent characteristics, such as strong plaintext sensitivity, a large key space, and excellent ciphertext statistical properties.

/pdf/an-image-encryption-method-based-on-the-feistel-network-and-gdjg1m4qre.pdf

An Image Encryption Method Based on the Feistel Network and Dynamic DNA Encoding

Shuffled frog leaping (SFL) is a population based, cooperative search metaphor inspired by natural memetics. Its ability of adapting to dynamic environment makes SFL become one of the most important memetic algorithms. In order to improve the algorithmpsilas stability and the ability to search the global optimum, a novel dasiacognition componentpsila is introduced to enhance the effectiveness of the SFL, namely frog not only adjust its position according to the best individual within the memeplex or the global best of population but also according to thinking of the frog itself. To validate the improved SFL (ISFL) method, numerous simulations were conducted to compare SFL and ISFL using six benchmark problems for continuous and discrete optimization. According to the simulation results, adding the cognitive behavior to SFL significantly enhances the performance of SFL in solving the optimization problems, and the improvements are more evident with the scale of the problem increasing.

An improved shuffled frog leaping algorithm with cognitive behavior

Image encryption is the most direct and effective technical means for protecting the security of image information. Based on the space filling property of the Hilbert curve and the infinite property of the H-geometric fractal, a new image encryption technique is proposed, which combines the pseudo-randomness of a hyperchaotic system and the sensitivity to initial values. First, the hash value of a plaintext image is calculated using the secure hash algorithm 3 (SHA-3) as the initial value of the piece-wise linear chaotic map (PWLCM) and Rossler chaotic systems, which associates the key with the plaintext. In addition, the chaotic sequences that are generated by the chaotic systems are used to scramble the global pixel positions and the pixel values of the images, thereby disturbing the distribution of the pixel positions and the pixel values. Second, the Hilbert curve and H-fractal are alternately used to scramble the local pixel positions and diffuse the pixel values twice. Finally, the ciphertext feedback is used to further enhance the confusion and diffusion characteristics of the algorithm in order to achieve higher security. The experimental results and security analysis show that the encryption technique has enough key space to resist exhaustive attacks and can effectively resist statistical attacks, differential attacks, noise attacks, and cropping attacks. It can be used for military, judicial, and other privacy-related digital images secure storage and network security transmissions.

Xuncai Zhang

Papers

An encryption scheme using DNA technology

Application of a novel IWO to the design of encoding sequences for DNA computing

An Image Encryption Method Based on the Feistel Network and Dynamic DNA Encoding

An improved shuffled frog leaping algorithm with cognitive behavior

A Chaos-Based Image Encryption Technique Utilizing Hilbert Curves and H-Fractals