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Yanina A. Assef
Researcher at University of Buenos Aires
Publications - 18
Citations - 230
Yanina A. Assef is an academic researcher from University of Buenos Aires. The author has contributed to research in topics: Epithelial sodium channel & Amiloride. The author has an hindex of 9, co-authored 15 publications receiving 218 citations.
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Journal ArticleDOI
Imatinib resistance in multidrug-resistant K562 human leukemic cells.
Yanina A. Assef,Fernanda Rubio,Georgina Pamela Colo,Silvana del Mónaco,Monica Alejandra Costas,Basilio A. Kotsias +5 more
TL;DR: The results indicate that the vincristine-resistant K562 cells which developed MDR phenotype, exhibited resistance to imatinib associated with a functional P-gp over-expression, suggesting that this resistance could be partially overcome by the inhibition of NF-kappaB pathway.
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Cell Migration in BeWo Cells and the Role of Epithelial Sodium Channels
Silvana del Mónaco,Gabriela Inés Marino,Yanina A. Assef,Alicia E. Damiano,Basilio A. Kotsias +4 more
TL;DR: Immunocytochemistry studies showed that the three ENaC subunits showed greater expression at the leading edge of the wound 3 h after injury, supporting the notion that these proteins participate in a postinjury signal.
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Epithelial Sodium Channel in a Human Trophoblast Cell Line (BeWo)
TL;DR: The results suggest that BeWo cells express ENaC subunits and that aldosterone was able to modulate a selective response by generating amiloride-sensitive sodium currents similar to those observed in other human tissues.
Journal Article
[Characterization of the epithelial sodium channel in human pre-eclampsia syncytiotrophoblast].
Silvana del Mónaco,Yanina A. Assef,Alicia E. Damiano,Elsa Zotta,Cristina Ibarra,Basilio A. Kotsias +5 more
TL;DR: The transcription of the alpha-ENaC mRNA was not detectable in preeclamptic placentas and the protein was not observed with immunohistochemistry staining, probably indicating a low protein expression level, which could lead to future studies concerning the mechanism involved in the pathophysiology of pre-eclampsia.
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The Migratory Capacity of Human Trophoblastic BeWo Cells: Effects of Aldosterone and the Epithelial Sodium Channel
TL;DR: It is suggested that aldosterone positively influences wound healing in BeWo cells, at least in part through methylation of the ENaC.