Y
Yanrui Zhu
Researcher at University of Western Ontario
Publications - 8
Citations - 65
Yanrui Zhu is an academic researcher from University of Western Ontario. The author has contributed to research in topics: Transfer RNA & Amino acid. The author has an hindex of 4, co-authored 8 publications receiving 36 citations.
Papers
More filters
Journal ArticleDOI
Modulating Mistranslation Potential of tRNASer in Saccharomyces cerevisiae
Matthew D. Berg,Yanrui Zhu,Julie Genereaux,Bianca Y Ruiz,Ricard A. Rodriguez-Mias,Tyler Allan,Alexander T Bahcheli,Judit Villén,Christopher J. Brandl +8 more
TL;DR: The goal of this work was to identify second-site substitutions in tRNASer that modulate mistranslation to different levels, and to suggest that the majority of the secondary mutations affect the stability of the tRNA in cells.
Journal ArticleDOI
The amino acid substitution affects cellular response to mistranslation.
Matthew D. Berg,Matthew D. Berg,Yanrui Zhu,Bianca Y Ruiz,Raphaël Loll-Krippleber,Joshua Isaacson,Bryan-Joseph San Luis,Julie Genereaux,Charles Boone,Judit Villén,Grant W. Brown,Christopher J. Brandl +11 more
TL;DR: It is predicted that the potential of mistranslation to exacerbate diseases caused by proteotoxic stress depends on the tRNA variant, and different naturally occurring mistranslating tRNAs have the potential to negatively influence specific diseases.
Journal ArticleDOI
Acceptor Stem Differences Contribute to Species-Specific Use of Yeast and Human tRNASer
Matthew D. Berg,Julie Genereaux,Yanrui Zhu,Safee Mian,Gregory B. Gloor,Christopher J. Brandl +5 more
TL;DR: The molecular mechanisms of translation are highly conserved in all organisms indicative of a single evolutionary origin, including the molecular interactions of tRNAs with their cognate aminoacyl-tRNA synthetase, which must be precise to ensure the specificity of the process.
Posted ContentDOI
Mistranslating tRNA identifies a deleterious S213P mutation in the Saccharomyces cerevisiae eco1-1 allele
Yanrui Zhu,Matthew D. Berg,Phoebe Yang,Raphaël Loll-Krippleber,Grant W. Brown,Christopher J. Brandl +5 more
TL;DR: The utility of mistranslating tRNA variants to identify functionally relevant mutations and identify eco1 as a reporter for mistranslation are indicated and it is proposed that mistranslations could be used as a tool to treat genetic disease.
Journal ArticleDOI
Chemical-Genetic Interactions with the Proline Analog L-Azetidine-2-Carboxylic Acid in Saccharomyces cerevisiae
Matthew D. Berg,Yanrui Zhu,Joshua Isaacson,Julie Genereaux,Raphaël Loll-Krippleber,Grant W. Brown,Christopher J. Brandl +6 more
TL;DR: Suggesting the potential of genetic changes to influence the cellular response to proteotoxic stress, overexpressing many of the genes that had a negative chemical-genetic interaction with AZC suppressed AZC toxicity.