Yasunori Sakakura

TL;DR: It is demonstrated that osteocytes in alveolar bone adjacent to the hyalinized PDL underwent cell death via apoptosis and "secondary necrosis" during orthodontic tooth movement, which may be associated with the subsequent bone resorption.

TL;DR: Growth of the incisor teeth may be involved in the time‐ and position‐specific resorption of Meckel's cartilage through local regulation of the RankL/OPG system in dental follicular cells and periosteal osteoblasts, whereas RANKL and OPG in chondrocytes seem to contribute to resOrption through regulation ofThe chondROclast function.

TL;DR: Results show that HGF expressed microfibrils and elastin, while HPLF expressed only microfibils for the experimental period, and suggest a biochemical basis for the different distribution of elastic system fibers of the gingiva and periodontal ligament in vivo.

TL;DR: Osteoclast differentiation in the process of ectopic bone formation induced by recombinant human bone morphogenetic protein 2 was examined to clarify the relationship between osteoclast development and rhBMP-2-induced bone formation and it is suggested that differentiation into polarized functional osteoclasts is accomplished when the osteoclast attach to the bone matrix.

TL;DR: The localization of MT1-MMP in the sealing zone of osteoclast in vivo suggests that the enzyme modifies the bone surface to facilitate the migration and attachment of osteoclasts as well as scavenging the resorption lacunae.