Yasuyuki Ohta

TL;DR: The present data show the possibility of increased autophagy in an animal model for ALS andAutophagy may be partially regulated by an mTOR signaling pathway in these animals.

TL;DR: Serum alpha-fetoprotein from 146 patients with hepatocellular carcinoma, other malignancies, and benign liver diseases, was fractionated by lectin-affinity electrophoresis coupled with the sensitive detection method of antibody-Affinity blotting to indicate that the simultaneous analysis of alpha- fetoprotein-L3 and alpha- Fetop protein-P4 is effective in monitoring the evolution of hepato cell carcinoma in cirrhotic patients.

TL;DR: To the authors' surprise, the transplanted iPS cells expanded and formed much larger tumors in mice postischemic brain than in sham-operated brain, showing a promising potential to provide neural cells after ischemic brain injury, if tumorigenesis is properly controlled.

TL;DR: The present results indicate that perivascular damage precedes the sequential changes of the disease, which are held in common between humans and the animal model of ALS, suggesting that the neurovascular unit is a potential target for therapeutic intervention in ALS.

TL;DR: In this paper, the authors investigated temporal changes of Keap1, Nrf2, and their downstream antioxidative proteins in post-ischemic mice brains with respect to spacial differences between the peri-infarct regions and the regions destined to infarct.