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Yen Chung Lai
Researcher at National Cheng Kung University
Publications - 6
Citations - 297
Yen Chung Lai is an academic researcher from National Cheng Kung University. The author has contributed to research in topics: Dengue virus & Dengue fever. The author has an hindex of 5, co-authored 6 publications receiving 176 citations.
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Journal ArticleDOI
Dengue virus nonstructural protein 1 activates platelets via Toll-like receptor 4, leading to thrombocytopenia and hemorrhage.
Chiao Hsuan Chao,Wei Chueh Wu,Yen Chung Lai,Pei Jane Tsai,Guey Chuen Perng,Yee Shin Lin,Trai Ming Yeh +6 more
TL;DR: Results suggest that the binding of DENV NS1 to TLR4 on platelets can trigger its activation, which may contribute to thrombocytopenia and hemorrhage during dengue infection.
Journal ArticleDOI
Dengue virus non-structural protein 1: a pathogenic factor, therapeutic target, and vaccine candidate
TL;DR: The pathogenic roles of DENV NS1 in hemorrhage and vascular leakage are reviewed, and the possibility of using NS1 as a therapeutic target and vaccine candidate is discussed.
Journal ArticleDOI
Antibodies Against Modified NS1 Wing Domain Peptide Protect Against Dengue Virus Infection.
Yen Chung Lai,Yung Chun Chuang,Ching Chuan Liu,Tzong Shiann Ho,Yee Shin Lin,Robert Anderson,Trai Ming Yeh +6 more
TL;DR: The modified NS1-WD peptide is a promising dengue vaccine candidate based on the epitope recognized by the anti-NS1 monoclonal Ab (mAb) 33D2 which recognizes a conserved NS1 wing domain (NS1- WD) region but not host proteins.
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Therapeutic Effects of Monoclonal Antibody against Dengue Virus NS1 in a STAT1 Knockout Mouse Model of Dengue Infection.
Shu Wen Wan,Shu Wen Wan,Pei Wei Chen,Chin Yu Chen,Yen Chung Lai,Ya Ting Chu,Chia Yi Hung,Han Lee,Hsuan Franziska Wu,Yung Chun Chuang,Jessica Lin,Chih Peng Chang,Shuying Wang,Ching Chuan Liu,Tzong Shiann Ho,Chiou Feng Lin,Chiou Feng Lin,Chien-Kuo Lee,Betty A. Wu-Hsieh,Robert Anderson,Trai Ming Yeh,Yee Shin Lin +21 more
TL;DR: In mouse model studies, treatment with mAb 2E8 shortened DENV-induced prolonged bleeding time and reduced viral Ag expression in the skin and suggested that NS1-specific mAb may be a therapeutic option against dengue disease.
Journal ArticleDOI
Minocycline suppresses dengue virus replication by down-regulation of macrophage migration inhibitory factor-induced autophagy
Yen Chung Lai,Yung Chun Chuang,Chih Peng Chang,Yee Shin Lin,Guey Chuen Perng,Han-Chung Wu,Shie Liang Hsieh,Trai Ming Yeh +7 more
TL;DR: Results suggest that inhibition of MIF‐induced autophagy by minocycline might represent an alternative therapeutic approach against DENV infection.