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Yi-Xiang Hong
Researcher at Xiamen University
Publications - 9
Citations - 156
Yi-Xiang Hong is an academic researcher from Xiamen University. The author has contributed to research in topics: Acacetin & AMPK. The author has an hindex of 3, co-authored 6 publications receiving 53 citations.
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Journal ArticleDOI
The Natural Flavone Acacetin Confers Cardiomyocyte Protection Against Hypoxia/Reoxygenation Injury via AMPK-Mediated Activation of Nrf2 Signaling Pathway.
Wei-Yin Wu,Yun-Da Li,Yu-Kai Cui,Chan Wu,Yi-Xiang Hong,Gang Li,Yao Wu,Ling-Jun Jie,Yan Wang,Gui-Rong Li +9 more
TL;DR: The results demonstrate for the first time that AMPK-mediated Nrf2 activation is involved in the cardiomyocytes protection of acacetin against hypoxia/reoxygenation injury by activating a series of intracellular signals involved in anti-oxidation, anti-inflammation, and anti-apoptosis.
Journal ArticleDOI
Doxorubicin cardiomyopathy is ameliorated by acacetin via Sirt1-mediated activation of AMPK/Nrf2 signal molecules.
TL;DR: It was found that the cardiac dysfunction and myocardial fibrosis induced by doxorubicin were significantly improved by acacetin in mice with impaired Nrf2/HO‐1 and Sirt1/pAMPK molecules, which is reversed by ac acetin treatment.
Journal ArticleDOI
Acacetin exerts antioxidant potential against atherosclerosis through Nrf2 pathway in apoE-/- Mice.
Yao Wu,Fei Song,Yun-Da Li,Jing-Zhou Li,Yu-Kai Cui,Yi-Xiang Hong,Weimin Han,Wei-Yin Wu,Ishan Lakhani,Gang Li,Yan Wang +10 more
TL;DR: In vivo, acacetin treatment remarkably attenuated atherosclerosis by increasing reductase levels in circulation and aortic roots, decreasing plasma inflammatory factor levels as well as accelerating lipid metabolism in Western diet‐fed apoE−/− mice.
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Cardiac senescence is alleviated by the natural flavone acacetin via enhancing mitophagy.
TL;DR: In this paper, the authors investigated using multiple experimental approaches whether the natural flavone acacetin could attenuate myocardial senescence in C57/BL6 mice and H9C2 rat cardiac cells induced by D-galactose.
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The roles of epicardial adipose tissue in heart failure.
TL;DR: Understanding the regulating mechanisms of EAT on heart failure may give rise to novel therapeutic targets and will open up innovative strategies to myocardial injury as well as in heart failure.