Yi-Zhong Gu

TL;DR: This review provides a detailed description of three signal transduction pathways that utilize PAS protein heterodimers to drive their transcriptional output and develops the idea that most eukaryotic PAS proteins can be classified by functional similarities, as well as by predicted phylogenetic relationships.

TL;DR: MOP3 mRNA expression overlaps in a number of tissues with each of its four potential partner molecules in vivo and is demonstrated that MOP3 interacts with MOP4, CLOCK, hypoxia-inducible factor 1alpha (HIF1alpha), and HIF2alpha.

TL;DR: In vitro studies reveal that HIF3alpha dimerizes with a prototype beta-class subunit, ARNT, and that the resultant heterodimer recognizes the hypoxia responsive element (HRE) core sequence, TACGTG.

TL;DR: A novel member of the PAS superfamily, MOP9 (member of PASsuperfamily), that maps to human chromosome 12p11 is characterized, which displays significant homology to the Drosophila circadian factor CYCLE and its putative mammalian ortholog MOP3/bMAL1.

TL;DR: RNAse protection assays demonstrate that in adult mice, the mHIF-1 alpha mRNA is expressed at high levels in kidney, heart, brain, thymus, and placenta, with moderate expression in liver, spleen, testis, and lung and much lower expression in skeletal muscle testis; these data suggest that Hif-1alpha, along with HIF-2 alpha, represents a new subclass of the bHLH-PAS superfamily.