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Yin Chen
Researcher at Chinese Center for Disease Control and Prevention
Publications - 16
Citations - 458
Yin Chen is an academic researcher from Chinese Center for Disease Control and Prevention. The author has contributed to research in topics: Medicine & Gene. The author has an hindex of 4, co-authored 8 publications receiving 280 citations.
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Journal ArticleDOI
A Family Cluster of Infections by a Newly Recognized Bunyavirus in Eastern China, 2007: Further Evidence of Person-to-Person Transmission
Changjun Bao,Xiling Guo,Xian Qi,Jianli Hu,Minghao Zhou,Jay K. Varma,Lunbiao Cui,Haitao Yang,Yongjun Jiao,John D. Klena,Luxun Li,Wen-yuan Tao,Xian Li,Yin Chen,Zheng Zhu,Ke Xu,Aihua Shen,Tao Wu,Hai-yan Peng,Zhifeng Li,Jun Shan,Zhiyang Shi,Hua Wang +22 more
TL;DR: Clinical and laboratory evidence confirmed that the patients of fever and thrombocytopenia occurring in a family cluster in eastern China in 2007 were caused by a newly recognized bunyavirus, SFTSV.
Journal ArticleDOI
Heterologous AD5-nCOV plus CoronaVac versus homologous CoronaVac vaccination: a randomized phase 4 trial
Jingxin Li,Lihua Hou,Xiling Guo,Pengfei Jin,Shipo Wu,Jiahong Zhu,Hongxing Pan,Xue Wang,Zexing Song,Jingxuan Wan,Lunbiao Cui,Junqiang Li,Yin Chen,Xue-Wen Wang,L. Jin,Jingxian Liu,Fengjuan Shi,Xiaoyu Xu,Tao Zhu,Wei Chen,Fengcai Zhu +20 more
TL;DR: In this paper , the authors evaluated the safety and immunogenicity of the recombinant adenovirus type 5 (AD5)-vectored COVID-19 vaccine Convidecia as a heterologous booster versus those of CoronaVac as homologous boost in adults previously vaccinated with CoronaVAC in an ongoing, randomized, observer-blinded, parallel-controlled phase 4 trial.
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Human Antibody Neutralizes Severe Fever with Thrombocytopenia Syndrome Virus, an Emerging Hemorrhagic Fever Virus
Xiling Guo,Li Zhang,Wenshuai Zhang,Ying Chi,Xiaoyan Zeng,Xian Li,Xian Qi,Qiu Jin,Xiao Zhang,Mingming Huang,Hua Wang,Yin Chen,Changjun Bao,Jianli Hu,Shuyi Liang,Lin Bao,Tao Wu,Minghao Zhou,Yongjun Jiao +18 more
TL;DR: A combinatorial human antibody library constructed from the peripheral lymphocytes of 5 patients who had recovered from SFTS suggests that MAb 4-5 can be used as a promising candidate molecule for immunotherapy against SFTSV infection.
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Safety and immunogenicity of heterologous boost immunisation with an orally administered aerosolised Ad5-nCoV after two-dose priming with an inactivated SARS-CoV-2 vaccine in Chinese adults: a randomised, open-label, single-centre trial
Rong Tang,B. Huang,Yin Chen,Lihua Hou,Jing Liu,Jin Zhong,Hongxing Pan,Fengjuan Shi,Xiao-Yu Xu,Xiaoyin Zhang,Lunbiao Cui,Wenjie Tan,Wei Chen,Jingxin Li,Shipo Wu,Xiling Guo,Xiao-Qin Chen,Li Hu,Feng Shi,Zhuo Li,Wenhui Tan,Wei Chen,Fengcai Zhu,Haitao Huang,J B Gou,Weixue Si,Xue Wang,Xiaoshuang Zhao,Tao Zhu +28 more
TL;DR: A heterologous booster vaccine with an orally administered aerosolised adenovirus type-5 vector-based COVID-19 vaccine (Ad5-nCoV) is safe and highly immunogenic in adults who have previously received two doses of CoronaVac as the primary series vaccination.
Journal ArticleDOI
A novel pyrosequencing assay for the detection of neuraminidase inhibitor resistance-conferring mutations among clinical isolates of avian H7N9 influenza virus.
Yuhua Qi,Huan Fan,Xian Qi,Zheng Zhu,Xiling Guo,Yin Chen,Yiyue Ge,Kangchen Zhao,Tao Wu,Yan Li,Yunfeng Shan,Minghao Zhou,Zhiyang Shi,Hua Wang,Lunbiao Cui +14 more
TL;DR: A reverse transcription (RT)-PCR assay coupled with pyrosequencing is described to identify the NA residues E120, H276, and R294 (N9 numbering) of H7N9 viruses, indicating resistance to oseltamivir.