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Methods Of Enzymatic Analysis

The Merck Index of Chemicals and Drugs An Encyclopedia for the Chemist, Pharmacist, Physician and Allied Professions Sixth edition Pp xiv + 1167 (Rahway, NJ: Merck and Company, Inc, 1952) 750 dollars; thumb-indexed, 8 dollars

The Merck Index

Diabetic autonomic neuropathy

IT may occasion some surprise to those men of science who are ill-acquainted with India, and who so frequently express the view that Governments are unappreciative of the importance of science to learn that as far back as 1886 the Government of India arranged for Dr. George (later Sir George) Watt, professor of botany in the Presidency College, Calcutta, to prepare a "Dictionary of the Economic Products of India". The six volumes of this standard work were published during the years 1889-99. In 1908 Sir George Watt published a condensed version, "The Commercial Products of India". Whatever the defects of these 'dictionaries', they have been of inestimable value to all interested in Indian natural products. The Wealth of India A Dictionary of Indian Raw Materials and Industrial Products. Raw Materials, Vol. 1. Pp. xxvii+254+39 plates. 15 rupees ; 24s. Industrial Products, Part 1. Pp. xii+182+8 plates. 8 rupees ; 12s. (New Delhi : Council of Scientific and Industrial Research, 1948.)

The Wealth of India

Oxidative stress and inflammation interact in the development of diabetic atherosclerosis. Intracellular hyperglycemia promotes production of mitochondrial reactive oxygen species (ROS), increased formation of intracellular advanced glycation end-products, activation of protein kinase C, and increased polyol pathway flux. ROS directly increase the expression of inflammatory and adhesion factors, formation of oxidized-low density lipoprotein, and insulin resistance. They activate the ubiquitin pathway, inhibit the activation of AMP-protein kinase and adiponectin, decrease endothelial nitric oxide synthase activity, all of which accelerate atherosclerosis. Changes in the composition of the gut microbiota and changes in microRNA expression that influence the regulation of target genes that occur in diabetes interact with increased ROS and inflammation to promote atherosclerosis. This review highlights the consequences of the sustained increase of ROS production and inflammation that influence the acceleration of atherosclerosis by diabetes. The potential contributions of changes in the gut microbiota and microRNA expression are discussed.

New insights into oxidative stress and inflammation during diabetes mellitus-accelerated atherosclerosis.

Cardiotoxicity linked to anticancer agents and cardioprotective strategy

Vascular adhesion protein-1 and microvascular diabetic complications

Natural Products as an Effective Treatment Option for Depression

Effect of Gmelina arborea extract in STZ induced type I diabetic rats

Multiple sclerosis (MS) is one of the leading causes of neurological disabilities and can be explained as a chronic, inflammatory, and autoimmune disease related to the central nervous system. Biomarkers play an important role in defining and understanding the various mechanisms involved in the progression of disease. The success of therapeutic treatment of MS can be measured by evaluating biomarkers, which can serve as a “surrogate end point” of clinical outcomes. Biomarkers of MS can be categorized as immune system biomarkers, blood–brain barrier disruption biomarkers, demyelination biomarkers, oxidative stress and excitotoxicity biomarkers, axonal/neuronal damage biomarkers, and remyelination and repair biomarkers. Studies have shown that natural products can modulate biomarkers of MS and can be used for its treatment. Polyunsaturated fatty acids, vitamins (specifically vitamin D), minerals, and trace elements all have promising effects on biomarkers of MS. Phytochemicals like adenanthin, cannabinoids, curcumin, epigallocatechin gallate, glucoraphanin, sulforaphane, hyperforin, matrine, plumbagin, and quercetin have also shown promise as potential treatments for MS. There is a wide scope for research in the domain of multiple sclerosis biomarkers and their modulation by natural products.

Yogesh A. Kulkarni

Papers

Cardiotoxicity linked to anticancer agents and cardioprotective strategy

Vascular adhesion protein-1 and microvascular diabetic complications

Natural Products as an Effective Treatment Option for Depression

Effect of Gmelina arborea extract in STZ induced type I diabetic rats

Biomarkers of Multiple Sclerosis and Their Modulation by Natural Products