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Yohko Akiyama
Researcher at Takeda Pharmaceutical Company
Publications - 33
Citations - 960
Yohko Akiyama is an academic researcher from Takeda Pharmaceutical Company. The author has contributed to research in topics: Dosage form & Controlled release. The author has an hindex of 14, co-authored 33 publications receiving 949 citations.
Papers
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Journal ArticleDOI
In vitro and in vivo evaluation of mucoadhesive microspheres prepared for the gastrointestinal tract using polyglycerol esters of fatty acids and a poly(acrylic acid) derivative.
TL;DR: Two types of polyglycerol ester of fatty acid (PGEF)-based microspheres were prepared and they adhered strongly to mucosa prepared from rat stomach and small intestine because each CP particle in the CPD-microsphere was hydrated and swelled with part of it remaining within the microsphere and part extending to the surface serving to anchor the micro Spheres to the mucus layer.
Patent
Controlled release composition
TL;DR: A controlled-release composition comprising a drug-containing core coated with a coating composition containing a water-insoluble substance and a swellable polymer having no basic groups is described in this article.
Journal ArticleDOI
Mucoadhesive Microspheres Containing Amoxicillin for Clearance of Helicobacter pylori
TL;DR: The mucocoadhesive microspheres more effectively cleared H. pylori from the gastrointestinal tract than the 0.5% methylcellulose suspension due to the prolonged gastrointestinal residence time resulting from mucoadhesion.
Journal ArticleDOI
Evaluation of Oral Mucoadhesive Microspheres in Man on the Basis of the Pharmacokinetics of Furosemide and Riboflavin, Compounds with Limited Gastrointestinal Absorption Sites
Yohko Akiyama,Naoki Nagahara,Eiji Nara,Megumi Kitano,Susumu Iwasa,Isamu Yamamoto,Isamu Yamamoto,Junichi Azuma,Junichi Azuma,Yasuaki Ogawa +9 more
TL;DR: The gastrointestinal transit of oral adhesive microspheres in man has been evaluated pharmacokinetically using furosemide and riboflavin, compounds with limited absorption sites in the upper small intestine.
Patent
Sustained release preparation
TL;DR: The sustained-release preparation of the present invention, which contains a dipeptidyl peptidase IV inhibitor and a hydrophilic polymer, can appropriately inhibit the DPP-IV activity, and is superior in convenience or compliance as discussed by the authors.