Compositions enriched with natural phyto-oestrogens or analogues thereof selected from Genistein, Daidzein, Formononetin and Biochanin A These may be used as food additives, tablets or capsules for promoting health in cases of cancer, pre-menstrual syndrome, menopause or hypercholesterolaemia

Health supplements containing phyto-oestrogens, analogues or metabolites thereof

Therapeutic methods of treatment, compositions and foodstuffs are described which contain isoflavone compounds described by general formula (I), in which Z is H, R1 is H, or RACO where RA is C1-10alkyl or an amino acid, R2 is H, OH, or ORB where RB is an amino acid, or CORA where RA is as previously defined, W is H, A is H or OH, and B is selected from (a), (b), (c), or W is H, and A and B taken together form a six-membered ring selected from (d), or W, A and B taken with the groups with which they are associated comprise (e), or W and A taken together with the groups with which they are associated comprise (f) and B is (g) wherein R3 is H, CORA where RA is as previously defined, CO2RC where RC is C1-10alkyl, or CORB where RB is as previously defined, R4 is H, CORD where RD is H, OH, C1-10alkyl or an amino acid, CO2RC where RC is as previously defined, CORE where RE is H, C1-10alkyl or an amino acid, COOH, CORC where RC is as previously defined, or CONHRE where RE is as previously defined, R5 is H, CO2RC where RC is as previously defined, or CORCORE where RC and RE are as previously defined, and where the two R5 groups are attached to the same group they are the same or different, R6 is H or hydroxy C1-10alkyl, X is preferably O, but may be N or S, and Y is (h) where R7 is H, or C1-10alkyl.

Therapeutic methods and compositions involving isoflavones

A method is provided for preventing or treating symptoms of menopause, premenstrual syndrome, or a condition resulting from reduced levels of endogenous estrogen, by administering to the woman an effective amount of an isoflavonoid. The invention also features a therapeutic dietary product, containing isoflavonoids, for preventing or treating symptoms of conditions resulting from reduced or altered levels of endogenous estrogen.

Method for treatment of menopausal and premenstrual symptoms

This invention relates to a novel heterocyclic compound represented by formula (I), wherein X is O or S, Y is vinylene, or a group of formula: -NHCO-, -NHSO2-, -OCO-, -OCH2-, -NHCOCO-, -NHCOCH=CH-, -NHCOCH2-, -NHCONH- or (a) (wherein R6 is lower alkyl), Z is heterocyclic group which may have one or more suitable substituent(s), or aryl which may have one or more suitable substituent(s), 1 = 0, 1 and the other symbols are as defined in the specification and a pharmaceutically acceptable salt thereof which are the inhibitors of bone resorption and bone metabolism, to processes for preparation thereof, to a pharmaceutical composition comprising the same and to a method for the treatment of diseases caused by abnormal bone metabolism in human being or an animal

Benzofuran derivatives useful as inhibitors of bone resorption.

Compositions, etc., which contain as the essential components a daizein-containing material and a microorganism capable of metabolizing daizein to give equol. These compositions are efficacious in preventing and relieving unidentified complaints in women of middle and old ages, involving climateric symptoms which cannot be efficaciously prevented nor relieved by any conventional means.

Isoflavone-containing composition

A compound of the formula
 wherein R is a hydrogen atom or a hydroxy group is effective for prevention or treatment of osteoporosis.

Method for treatment of osteoporosis

Novel isoflavone derivatives of the formula:
 exhibit mild estrogenic activity, and are of value as an agent for prevention and treatment of osteoporosis.

Isoflavone derivatives, their production and use

A compound of the general formula
 [wherein R is a hydrogen atom or a lower alkyl group] is effective for treatment of hypoovarianism.

Compounds and pharmaceutical compositions for treatment of hypoovarianism

PURPOSE: The titled remedy, containing an isoflavone derivative, and capable of treating hypoovarianism such as climacteric disturbance or infertility by enhancing the action of estrogen. CONSTITUTION: A remedy for hypoovarianism obtained by incorporating a compound of the formula (R is H, or lower alkyl), e.g. 7-hydroxy-isoflavone; white or yellowish brown crystal compound, soluble readily in dimethylformamide (DMF), etc., somewhat easily in ethanol, etc. and sparingly in water. The compound of the formula individually has no action of estrogen (hereinafter abbreviated to E) but effect on enhancement of the E action and is capable of enhancing the overial E action with reduced secretion in patients with climacteric disturbance or infertility and usable for treating the diseases. The dose thereof is 1W30mg/ kg/day, preferably 5W10mg/kg/day for oral administration and administered once a day. The dose is, if necessary, divided into two or three portions. COPYRIGHT: (C)1984,JPO&Japio

Remedy for hypoovarianism

NEW MATERIAL:The 4H-1-benzopyran-4-one derivative of formula I . EXAMPLE: 7-Isopropoxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one. USE: A remedy for osteoporosis, exhibiting mild estrogen-action by oral administration, and free from the side effects in contrast to the conventional estrogen preparation. PREPARATION: The compound of formula I can be produced by the isopropylation of the hydroxyl compound of formula II e.g. with the isopropyl halide of formula III (X is halogen such as Cl, Br etc.). COPYRIGHT: (C)1985,JPO&Japio

Yoichi Sawa

Papers

Method for treatment of osteoporosis

Isoflavone derivatives, their production and use

Compounds and pharmaceutical compositions for treatment of hypoovarianism

Remedy for hypoovarianism

Novel 4h-1-benzopyran-4-one derivative, its preparation and its use