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Yong-Yue Gao
Researcher at Nanjing University
Publications - 41
Citations - 1101
Yong-Yue Gao is an academic researcher from Nanjing University. The author has contributed to research in topics: Neuroprotection & Medicine. The author has an hindex of 17, co-authored 30 publications receiving 607 citations.
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Fucoxanthin provides neuroprotection in models of traumatic brain injury via the Nrf2-ARE and Nrf2-autophagy pathways
Li Zhang,Handong Wang,Youwu Fan,Yong-Yue Gao,Xiang Li,Zhigang Hu,Ke Ding,Yujie Wang,Xiaoliang Wang +8 more
TL;DR: It is found that fucoxanthin alleviated TBI-induced secondary brain injury, including neurological deficits, cerebral edema, brain lesion and neuronal apoptosis, and the up-regulation of malondialdehyde (MDA) and the activity of glutathione peroxidase (GPx) were reversed by fu Coxanthin treatment.
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Peroxiredoxin 2 activates microglia by interacting with Toll-like receptor 4 after subarachnoid hemorrhage
Yue Lu,Xiang-Sheng Zhang,Zihuan Zhang,Xiao-Ming Zhou,Yong-Yue Gao,Guang-Jie Liu,Han Wang,Ling-Yun Wu,Wei Li,Chun-Hua Hang +9 more
TL;DR: Extracellular Prx2 in CSF after SAH is a DAMP which resulted in microglial activation via TLR4/MyD88/NF-κB pathway and then neuronal apoptosis and may be a potential indicator of brain injury and prognosis.
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Aucubin alleviates oxidative stress and inflammation via Nrf2-mediated signaling activity in experimental traumatic brain injury
Han Wang,Xiao-Ming Zhou,Ling-Yun Wu,Guang-Jie Liu,Wei-Dong Xu,Xiang-Sheng Zhang,Yong-Yue Gao,Tao Tao,Yan Zhou,Yue Lu,Juan Wang,Chu-Lei Deng,Zong Zhuang,Chun-Hua Hang,Wei Li +14 more
TL;DR: The data suggest that Au provides a neuroprotective effect in TBI mice model by inhibiting oxidative stress and inflammatory responses; the mechanisms involve triggering Nrf2-induced antioxidant system.
Journal ArticleDOI
Protective Effects of Quercetin on Mitochondrial Biogenesis in Experimental Traumatic Brain Injury via the Nrf2 Signaling Pathway
Xiang Li,Handong Wang,Yong-Yue Gao,Liwen Li,Chao Tang,Guodao Wen,Yuan Zhou,Meng-Liang Zhou,Lei Mao,Youwu Fan +9 more
TL;DR: Observations suggest that quercetin improves mitochondrial function in TBI models, possibly by activating the Nrf2 pathway.
Journal ArticleDOI
Interplay between VEGF and Nrf2 regulates angiogenesis due to intracranial venous hypertension.
Liwen Li,Hao Pan,Handong Wang,Xiang Li,Xiaomin Bu,Qiang Wang,Yong-Yue Gao,Guodao Wen,Yali Zhou,Zixiang Cong,Youqing Yang,Chao Tang,Zhengwei Liu +12 more
TL;DR: It is suggested that the interplay between Nrf2 and VEGF can contribute to VH-induced angiogenesis in brain AVMs pathogenesis.