Yong Zhang

TL;DR: The inhibitory effect of salvinorin A on striatal dopamine levels may contribute to its induction of conditioned place aversion and decreases in locomotion in mice.

TL;DR: The blockade of the cocaine-induced rise in striatal dopamine may contribute to both dynorphin’s ability to prevent the development of cocaine- induced conditioned place preference and to attenuate the increase in locomotor activity.

TL;DR: The lower number of infusions of oxycodone self-administered by adolescent mice, and their later increased striatal dopamine in response to the lowest dose of oxy codone (not found in adults), suggest differential sensitivity to the reinforcing and neurobiological effects of oxyCodone in the younger mice.

TL;DR: Findings suggest that R-84760 decreases dopamine levels in the caudate putamen through kappa-opioid receptors, which may contribute to its blockade of cocaine-induced increases in dopamine levels, cocaine- induced conditioned place preference and the associated increases in locomotor activity.

TL;DR: Interestingly, levels of P-Thr34- and P-Ser130-DARPP-32 were reduced after self-administration of cocaine in wild-type mice, suggesting that phosphorylation states of Thr 34- and Ser130- DAR PP-32 play important roles in modulating the reinforcing effects of cocaine.